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Author Topic: European Descendants Carry Brunt of New Gene Mutations
geeskee55
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Did this slip beneath the radar?

http://www.bloomberg.com/news/2012-11-28/european-descendants-carry-brunt-of-new-gene-mutations.html

Almost three quarters of gene mutations occurred within the last 5 to 10 millennia of humans’ 200,000 years existence, and those of European descent have most of the harmful ones, an analysis of people in the U.S. showed.

About 14 percent of mutations scientists identified were found to be harmful, according to a gene study of 6,500 Americans published today in the journal Nature. About 86 percent of those variants arose in people with European heritage in the last 5,000 years, the research found.

The exploding population growth of humans enabled DNA errors to occur more rapidly, said study author Joshua Akey, an associate professor of genome sciences at the University of Washington in Seattle. People with European ancestry have most of the new deleterious mutations because the population boom among Europeans was more recent and natural selection hasn’t yet removed them, he said .

“There’s an enormous amount of recently arisen, rare mutations that’s directly attributable to the explosive population growth over the last two to four generations,” said Akey in a telephone interview.

The world’s population was 6.9 billion in 2010, more than doubling from 2.5 billion in 1950, according to United Nations data. The population boom may mean that unusual combinations may affect more people, numerically, while remaining rare relative to the world population, Akey said.
New Mutations

More people allow for rare variations to come up more often and for new mutations to appear, Akey said. The growing population also makes it more likely that new mutations will be introduced, such as those linked to autism, leading to an increase in certain diseases.

The findings are also consistent with the “out of Africa” hypothesis of human evolution, which holds that modern humans emerged in Africa before spreading across the rest of the world, according to the researchers. Events such as the Black Death, a plague which killed about a third of the people in Europe, could be seen through their effects on the genome, said Eric Topol, a professor of translational genomics at the Scripps Research Institute in La Jolla, California.

Today’s data may provide other hints of how the human population expanded, much like tree rings can provide records of the past weather, Topol said.

“This helps us understand bottlenecks and how humans evolved,” Topol said. He wasn’t involved in the study. Now when scientists see new genes or mutations, they “can also begin to ask when did they crop up,” he said.
Disease Clues

What’s more, the data may help doctors identify the genetic basis of disease, he said. Researchers typically look for frequent variants in common ailments, such as diabetes and heart disease. Today’s results suggest that rare variations occur so often that they contribute more than once thought to common illnesses.

Because changes in the population have been so rapid and studies until this point relied on much smaller samples, scientists haven’t been able to detect increasing mutations.

For instance, scientists know from skeletons that humans have gotten larger over the last 1,000 years, though smaller analyses of the exome, the part of the genome that codes proteins, didn’t find any signs of that growth in their data.

“It turns out the reason we couldn’t see it before is because the growth happened so recently that you need thousands to see it,” Akey said. “There’s a massive signature of growth.”

The project, funded by the National Heart, Lung, and Institute Blood, was begun in September 2008. Further research may include sequencing parts of the genome that don’t code for proteins, Akey said. Some of these non-coding regions regulate the genes that code proteins, and may also be important.


Can someone clarify the "deleterious mutations" comment in bold? The only way to remove these mutations is to procreate outside of their "people", right?

If so called whites continue procreating only with each other, more recessive/deleterious traits will express, correct?

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Ponsford
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Europeans are all distant cousins-Identical By Descent except Spain and Italy.Deleterious mutations need time to be "scrubbed" from the genome.European scientist are aware of the problem that is why they are focusing on gene therapy,stem cells and tranplantation of organs,they are even transplanting faecal matter from their bowels to combat the bacteria-Clostridium Difficelle.
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Mike111
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The Albinos self-conscious instinct to herd together and mate together has keep them in the almost pure Albino state for thousands of years.

Note this previous post from Doxie:

quote:
Originally posted by DHDoxies:
My tastes haven't changed where men are concerned, I LOVE my White brothers, particularly Scottish, German, & Finnish men, preferably with Blond hair & blue eyes, oh and I like my men long haired as well with no facial or body hair.

Doxie dear, in view of this new info, might I suggest that you re-consider your choice of sexual partner.
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Badumtish
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quote:
Can someone clarify the "deleterious mutations" comment in bold? The only way to remove these mutations is to procreate outside of their "people", right?
Depends. You can create a Punnett Square to see the chance of it being transmitted. If both parents are homozygous recessive then it will certainly be passed on. Statistically speaking, given its higher rate of incidence amongst European populations, it would be beneficial for them to procreate with other populations (or anyone who doesn't have these mutations in their genotype), as the non-deleterious dominant allele will express itself in the progeny.

quote:
If so called whites continue procreating only with each other, more recessive/deleterious traits will express, correct? [/QB]
Yes, it is similar to incestuous offspring: the chances of deleterious ailments increases significantly (but obviously at a slower rate in this case, given the size of the European population).
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Ponsford
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Most deleterious mutations lead to inborn errors of metabolism.The specific enzymes incapable of catlysing the specific subtrates which leads to "build up" in the system causing such diseases like Tay-Sach.
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CelticWarrioress
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I don't think so Mike oh evil Black racist one. I shall not be a contributor to the destruction of my people.

Ponsford Tay-Sach is not a problem in Whites only in Jews.

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Mike111
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^It was a word to the wise, use it or not, as you wish. To some being "full-filled" is important, to others, not so important - at least that's what they say.
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