Abstract: Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 new Island Melanesian genomes. In aggregate, we recovered 1.34 Gb and 303 Mb of the Neandertal and Denisovan genome, respectively. We leverage these maps of archaic sequence to show that Neandertal admixture occurred multiple times in different non-African [sic DD] populations, characterize genomic regions that are significantly depleted of archaic sequence, and identify signatures of adaptive introgression.
Vernot et al., Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals, Science 17 Mar 2016, DOI: 10.1126/science.aad9416
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We evaluated our approach through coalescent simulations (figs. S5 and S6) and by analyzing African populations (fig. S7). Archaic match P values calculated from null coalescent simulations without archaic admixture and significant S* sequences in African individuals show similar distributions (Fig. 2A), consistent with little to no Neandertal or Denisovan ancestry in most African populations. Notably, Luhya and Gambians do show evidence of having some Neanderthal ancestry (fig. S8 and table S6), most likely inherited indirectly through recent admixture with non-Africans (20). In Europeans, we see a strong skew of Neandertal, but not Denisovan, match P values toward zero (Fig. 2A). In contrast, Melanesians exhibit a marked skew of both Neandertal and Denisovan match P values toward zero (Fig. 2A). http://science.sciencemag.org/content/early/2016/03/16/science.aad9416.full
Regions depleted of archaic lineages are significantly enriched for genes expressed in specific brain regions, particularly in the developing cortex and adult striatum. A large region depleted of archaic sequence spans 11 Mb on chromosome 7 and contains the FOXP2 gene, which has been associated with speech and language. This region is also significantly enriched for genes associated with autism spectrum disorders
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posted
"Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians,"
lol Interesting. However, this one was very predictable. lol
Posts: 22249 | From: האם אינכם כילדי הכרית אלי בני ישראל | Registered: Nov 2010
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quote:Originally posted by DD'eDeN: from Science article:
We evaluated our approach through coalescent simulations (figs. S5 and S6) and by analyzing African populations (fig. S7). Archaic match P values calculated from null coalescent simulations without archaic admixture and significant S* sequences in African individuals show similar distributions (Fig. 2A), consistent with little to no Neandertal or Denisovan ancestry in most African populations. Notably, Luhya and Gambians do show evidence of having some Neanderthal ancestry (fig. S8 and table S6), most likely inherited indirectly through recent admixture with non-Africans (20). In Europeans, we see a strong skew of Neandertal, but not Denisovan, match P values toward zero (Fig. 2A). In contrast, Melanesians exhibit a marked skew of both Neandertal and Denisovan match P values toward zero (Fig. 2A). http://science.sciencemag.org/content/early/2016/03/16/science.aad9416.full
It's remarkable that at first there was no Neandertal DNA in Africans. Makes you wonder, howcome, what happened?
Posts: 22249 | From: האם אינכם כילדי הכרית אלי בני ישראל | Registered: Nov 2010
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quote:Originally posted by DD'eDeN: from Science article:
We evaluated our approach through coalescent simulations (figs. S5 and S6) and by analyzing African populations (fig. S7). Archaic match P values calculated from null coalescent simulations without archaic admixture and significant S* sequences in African individuals show similar distributions (Fig. 2A), consistent with little to no Neandertal or Denisovan ancestry in most African populations. Notably, Luhya and Gambians do show evidence of having some Neanderthal ancestry (fig. S8 and table S6), most likely inherited indirectly through recent admixture with non-Africans (20). In Europeans, we see a strong skew of Neandertal, but not Denisovan, match P values toward zero (Fig. 2A). In contrast, Melanesians exhibit a marked skew of both Neandertal and Denisovan match P values toward zero (Fig. 2A). http://science.sciencemag.org/content/early/2016/03/16/science.aad9416.full
It's remarkable that at first there was no Neandertal DNA in Africans. Makes you wonder, howcome, what happened?
they said it was recent and the countries involved are coastal, Kenya and Gambia. Interestingly the Yoruba in Gambia had the higher amount not the Kenyans If that is recent I wonder how it might correlate to haplogroups of these populations
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posted
If anyone were to try to put a racist spin on this issue they would first have to convince people that the Neanderthals were intellectually superior to Anatomically Modern Humans. I don't see how that could ever happen.
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quote:Originally posted by DD'eDeN: from Science article:
We evaluated our approach through coalescent simulations (figs. S5 and S6) and by analyzing African populations (fig. S7). Archaic match P values calculated from null coalescent simulations without archaic admixture and significant S* sequences in African individuals show similar distributions (Fig. 2A), consistent with little to no Neandertal or Denisovan ancestry in most African populations. Notably, Luhya and Gambians do show evidence of having some Neanderthal ancestry (fig. S8 and table S6), most likely inherited indirectly through recent admixture with non-Africans (20). In Europeans, we see a strong skew of Neandertal, but not Denisovan, match P values toward zero (Fig. 2A). In contrast, Melanesians exhibit a marked skew of both Neandertal and Denisovan match P values toward zero (Fig. 2A). http://science.sciencemag.org/content/early/2016/03/16/science.aad9416.full
It's remarkable that at first there was no Neandertal DNA in Africans. Makes you wonder, howcome, what happened?
they said it was recent and the countries involved are coastal, Kenya and Gambia. Interestingly the Yoruba in Gambia had the higher amount not the Kenyans If that is recent I wonder how it might correlate to haplogroups of these populations
???
LOL SMH @ this euronut.
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All Non-Africans Part Neanderthal, Genetics Confirm
The ancestors of Neanderthals left Africa about 400,000 to 800,000 years ago. They evolved over the millennia mostly in what are now France, Spain, Germany and Russia. They went extinct, or were simply absorbed into the modern human population, about 30,000 years ago.
[...]
This work goes back to nearly a decade ago, when Labuda and his colleagues identified a piece of DNA, called a haplotype, in the human X chromosome that seemed different. They questioned its origins.
Fast forward to 2010, when the Neanderthal genome was sequenced. The researchers could then compare the haplotype to the Neanderthal genome as well as to the DNA of existing humans. The scientists found that the sequence was present in people across all continents, except for sub-Saharan Africa, and including Australia.
posted
You are being foolish and paranoid. These are recent discoveries and there is a sequence that Neanderthal DNA was found in various specimens of various populations. You simply dont know the history of the research nor what the relevance of it is
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quote: Some of the human X chromosome originates from Neanderthals and is found exclusively in people outside Africa, according to an international team of researchers led by Damian Labuda of the Department of Pediatrics at the University of Montreal and the CHU Sainte-Justine Research Center. The research was published in the July issue of Molecular Biology and Evolution.
Genome sequences harvested from Neanderthal bones have previously confirmed that the two groups mated, and that about 2% of the genomes of people who descend from Europeans, Asians and other non-Africans is Neanderthal 3, 4. The Neanderthal contributions are peppered across the genome, and different people have different Neanderthal genes.
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