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Some questions for the black supremacists and melanin theorists
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[QUOTE]Originally posted by IronLion: [QB] [QUOTE]Originally posted by IronLion: [qb] [QUOTE]Originally posted by InsertNameHere: [qb] It obviously has functional consequences. It also obviously lightens the skin, what it isn't obviously is albinism. Edit: Though paleness is technically a symptom of albinism. So you could be correct to say the gene creates some of the same symptoms as albinism. [/qb][/QUOTE]I like that your edit, you are now seeing better... maybe there is hope yet for you... I will tell you even more.... :D :D :D SLC24A5 is a gene common in all humanity including Africans and Asians and Europeans. It is one of the makers of ancestry. In a natural or ancestral form it contributes to the coding of the proteins necessary for the production of melanin. In a "mutated" or "derived" form, it malfunctions and causes symptoms of Albinism. Africans and Asians carry the anscestral form of SLC24A5. Europeans carry the malfunctioning, mutated, or derived allelle which is responsible for albinism and other physiological dysfunctions... I will provide sources.... SLC24A5 has a striking pattern of variation in human populations. A coding variant in the gene has previously been described as one of a set of ancestry-informative markers. The ancestral form encodes alanine at residue 111, whereas a derived allele encodes threonine. Alanine is present at this position in all known members of the SLC24 subfamily of proteins, suggesting the change to threonine has functional consequences . The derived variant is universally present on all European chromosomes analysed, while chromosomes of African and Asian origin almost invariably carry the ancestral form... See http://www.nature.com/ejhg/journal/v14/n9/full/5201659a.html -------------------------------------------------------------------------------- [/qb][/QUOTE]SLC24A5 often occurs in Europeans in its homozygote form. The homozygote forms of mutated or derived genes often cause all kinds of health problems. Albinism as we all know is associated with homozygote skin colour affecting allelles. The high frequency of homozygote forms of SLC24A5 in Europeans indicate inbreeding over a long period of time. We know that inbreeding leads to higher frequencies of albinism. I will post my sources now: Furthermore, analysis of the HapMap Consortium data6 found that SLC24A5 was within a chromosomal region that has a striking reduction of heterozygosity of SNPs in the European population. In fact, at 150 kb it is the longest such segment identified in the genome.1 Such a long conserved homozygous haplotype indicates that there has been strong selection on a gene or genes, which has swept this segment across the population, and selection for homozygosity eliminated recombination between SNPs, which maintained a long haplotype. http://www.nature.com/ejhg/journal/v14/n9/full/5201659a.html [/QB][/QUOTE]
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