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A new study concludes that all Ashkenazi Jews can trace their ancestry to a “bottleneck” of just 350 individuals, dating back to between 600 and 800 years ago.
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The study, published in the Nature Communications journal Tuesday, was authored by Shai Carmi, a computer science professor at Columbia University, and more than 20 medical researchers from Yale, Columbia, Yeshiva University’s Albert Einstein College of Medicine, Memorial Sloan-Kettering Cancer Center, Hebrew University of Jerusalem and other institutions.
Researchers analyzed the genomes of 128 Ashkenazi Jews and compared them to those of non-Jewish Europeans in order to determine which genetic markers are unique to Ashkenazi Jews. They found that the Ashkenazi Jews’ genetic similarities were so acute that one of the study’s researchers, Columbia professor Itsik Pe’er, told the Live Science website that among Ashkenazi Jews, “everyone is a 30th cousin.”
The findings will enable researchers to catalog nearly all of the genetic variations from the founding population, the study’s authors said. Such thorough genetic cataloging could help clinicians interpret individual genetic mutations, improve disease mapping and provide insight into the histories of Middle Eastern and European populations, the study said.
The catalog of complete Ashkenazi Jewish genomes should help identify the disease-causing mutations that the progenitors of Ashkenazi Jewry they passed on. Until now, data has only been available for a small subset of common Ashkenazi DNA markers – about one in every 3,000 letters of DNA. The findings are also expected to help with disease research in other ethnic groups.
“Our study is the first full DNA sequence dataset available for Ashkenazi Jewish genomes,” said Itzik Pe’er, an Israeli computer scientist at Columbia University, who led the study. “With this comprehensive catalog of mutations present in the Ashkenazi Jewish population, we will be able to more effectively map disease genes onto the genome and thus gain a better understanding of common disorders. We see this study serving as a vehicle for personalized medicine and a model for researchers working with other populations.”
Ashkenazi Jews are known to have origins in the Levant, which Israel is smack dab in the middle of. But exactly who “European” Ashkenazi Jews are has long been debated. An analysis of the gene database shows that the original Ashkenazi Jews were about half European and half Middle Eastern. They lived in the medieval era, about 600 to 800 years ago, according to the analysis – and numbered just 350 or so people.
posted New Genetic Research Confirms Koestler’s “Khazar” Theory! Ashkenazi Jews Are Not The Jews of The Bible!
The Missing Link of Jewish European Ancestry: Contrasting the Rhineland and the Khazarian Hypotheses
The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The “Rhineland Hypothesis” depicts Eastern European Jews as a „population isolate” that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the „Khazarian Hypothesis” suggests that Eastern European Jew descended from the Khazars, an amalgam of Turkic clans that settled the Caucasus in the early centuries CE and converted to Judaism in the 8th century. Mesopotamian and Greco-Roman Jews continuously reinforced the Judaized Empire until the 13th century. Following the collapse of their empire, the Judeo-Khazars fled to Eastern Europe. The rise of European Jewry is therefore explained by the contribution of the Judeo-Khazars. Thus far, however, the Khazar's contribution has been estimated only empirically, as the absence of genome-wide data from Caucasus populations precluded testing the Khazarian Hypothesis. Recent sequencing of modern Caucasus populations prompted us to revisit the Khazarian Hypothesis and compare it with the Rhineland Hypothesis. We applied a wide range of population genetic analyses to compare these two hypotheses. Our findings support the Khazarian Hypothesis and portray the European Jewish genome as a mosaic of Caucasus, European, and Semitic ancestries, thereby consolidating previous contradictory reports of Jewish ancestry. We further describe major difference among Caucasus populations explained by early presence of Judeans in the Southern and Central Caucasus. Our results have important implications on the demographic forces that shaped the genetic diversity in the Caucasus and medical studies. It concentrates on the compelling genetic evidence that eastern European Jewry’s roots are not just in the Mid-East but, perhaps even more so, in the Caucasus, the mountainous heartland of ancient Khazaria.
Elhaik says that because of dissatisfaction with current theory he and others are forced to look again at the possibility that the Mid-East and Semitic genes present in eastern European Jewry may primarily have come from the east. His team is compelled to research this possibility because genetic testing of Ashkenazim continues to reveal a high percentage of genes particular only to the relatively isolated, mountainous region of the Caucasus.
Here are some of Dr. Elhaik’s conclusions as a result of his first genetic study of Ashkenazim:
- Early German historians bridged the historical gap simply by linking modern Jews directly to the ancient Judeans (Figure 1); a paradigm that was quickly embedded in medical science and crystallized as a narrative. Many have challenged this narrative (Koestler 1976; Straten 2007), mainly by showing that a sole Judean ancestry cannot account for the vast population of Eastern European Jews in the beginning of the 20th century without the major contribution of Judaized Khazars and by demonstrating that it is in conflict with anthropological, historical, and genetic evidence (Dinur 1961; Patai and Patai 1975; Baron 1993).
- - Our PC, biogeographical estimation, admixture, IBD, ASD, and uniparental analyses were consistent in depicting a Caucasus ancestry for European Jews. Our first analyses revealed tight genetic relationship of European Jews and Caucasus populations and pinpointed the biogeographical origin of European Jews to the south of Khazaria (Figures 3,4). Our later analyses yielded a complex multi-ethnical ancestry with a slightly dominant Near Eastern-Caucasus ancestry, large Southern European and Middle Eastern ancestries, and a minor Eastern European contribution…
- We show that the Khazarian Hypothesis offers a comprehensive explanation to the results…By contrast, the Rhineland Hypothesis could not explain the large Caucasus component in European Jews, which is rare in Non-Caucasus populations (Figure 5) and the large IBD regions shared between European Jews and Caucasus populations attesting to their common origins. A major difficulty with the Rhineland Hypothesis, in addition to the lack of historical and anthropological evidence to the multi-migration waves from Palestine to Europe (Straten 2003; Sand 2009), is to explain the vast population expansion of Eastern European Jews from 50 thousand (15th century) to 8 million (20th century). This growth could not possibly be the product of natural population expansion (Koestler 1976; Straten 2007), particularly one subjected to severe economic restrictions, slavery, assimilation, the Black Death and other plagues, forced and voluntary conversions, persecutions, kidnappings, rapes, exiles, wars, massacres, and pogroms (Koestler 1976; Sand 2009). Such an unnatural growth rate (1.7-2% annually) over half a millennia, affecting only Jews residing in Eastern Europe is commonly explained by a miracle (Atzmon et al. 2010). Unfortunately, this divine intervention explanation poses a new kind of problem – it is not science. Our findings reject the Rhineland Hypothesis and uphold the thesis that Eastern European Jews are Judeo-Khazars in origin. Further studies are necessary to confirm the magnitude of the Khazars demographic contribution to the demographic presence of Jews in Europe (Polak 1951; Dinur 1961; Koestler 1976; Baron 1993; Brook 2006). The American Peoples Encyclopedia … for 1954 at 15-292 records the following in reference to the Khazars: “In the year 740 A.D. the Khazars were officially converted to Judaism. A century later they were crushed by the incoming Slavic-speaking people and were scattered over central Europe where they were known as Jews. - According to the standard Jewish Encyclopedia 96% of all the Jews known to the world today are descendents of the Khazar tribes of Russia, Eastern Europe and western Mongolia.
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