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[QUOTE]Originally posted by DD'eDeN: [QB] https://carta.anthropogeny.org/moca/topics/duf1220-domain-copy-number Human Uniqueness Compared to "Great Apes": Likely Difference MOCA Domain: Genomics MOCA Topic Authors: Veronica Searles Quick James Sikela DUF1220 is a 65 amino acid protein domain that has undergone a striking human specific copy number expansion, resulting in the addition of over 80 new copies of the domain in humans compared to chimps. DUF1220 copy number increases as a function of a species' evolutionary proximity to humans with a trend of 28 copies being added every million years. The greatest number of copies (>270) is found in human while mice and rats have only 1 copy. DUF1220 sequences have also undergone recent positive selection and, while widely expressed, show high levels of expression in the fetal brain (Diskin et al. 2009) and in neurons (Popesco et al. 2006). The DUF1220 copy number in creases in humans involved both domain amplification and gene duplication (NBPF family), with the great majority of copies mapping to the 1q21.1 region. [/QB][/QUOTE]
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