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[QUOTE]Originally posted by DD'eDeN: [QB] "Most alleles associated with light and dark pigmentation in our dataset are estimated to have originated prior to the origin of modern humans ~300 ky ago (26). In contrast to the lack of variation at MC1R, which is under purifying selection in Africa (61), our results indicate that both light and dark alleles at MFSD12, DDB1, OCA2, and HERC2 have been segregating in the hominin lineage for hundreds of thousands of years (Fig. 4). Further, the ancestral allele is associated with light pigmentation in approximately half of the predicted causal SNPs; Neanderthal and Denisovan genome sequences, which diverged from modern human sequences 804 kya (62), contain the ancestral allele at all loci. These observations are consistent with the hypothesis that darker pigmentation is a derived trait that originated in the genus Homo within the past ~2 million years after human ancestors lost most of their protective body hair, though these ancestral hominins may have been moderately, rather than darkly, pigmented (63, 64)." N. G. Crawford et al., Science 10.1126/science.aan8433 (2017). > Crawford, N.G., Kelly, D.E., Hansen, M.E., > Beltrame, > M.H., Fan, S., Bowman, S.L., Jewett, E., Ranciaro, > A., > Thompson, S., Lo, Y. and Pfeifer, S.P., 2017. > Loci > associated with skin pigmentation identified in > African populations. Science, p.eaan8433. [/QB][/QUOTE]
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