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peer review demolishes Winters M-173
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[QUOTE]Originally posted by Clyde Winters: [QB] [QUOTE]Originally posted by Quetzalcoatl: Mainly spam. Your comment. continues your delusion that there is M1 in India. Either it is mental block, or you are so invested in this falsehood, that losing it will endanger all your work because the Dravidians are the key for your extension of "proto-Saharans" to other parts of the world. M1 and M3 are two things 1)labels for a series of mutations and 2) designations of the haplogroups people have. One can change role one as nomenclature conflicts arise without making role two disappear. You can claim that haplogroup M1 is present in India till the cows come home [b]BUT There are no people in India[/b] with a haplogroup with SNPs (T195C! G6446A T6680C C12403T A12950c G16129A! T16189C! T16249C T16311C) i.e. the real M1. on the other hand there are millions in India with haplotype containing the SNPs (T482C T16126C ) i.e. M3. Sun, C. et al. The Dazzling Array of Basal Branches in the mtDNA Macrohaplogroup M from India as Inferred from Complete Genomes, [b]Mol. Biol. Evol.[/b] 23(3):683690. [QUOTE] p. 688-689 A particular case in question is the origin of haplogroup M1, which is mainly found in Northeast Africa and the Near East (Quintana-Murci et al. 1999). Due to the fact that M1 bears variant nucleotides, for example, at site 16311 in common with haplogroup M4, at 16129 with M5, and at 16249 with haplogroup M34, it has been proposed that M1 might have some affinity with Indian M haplogroups (Roychoudhury et al. 2001). This inference, however, could not receive support from our complete sequencing information. Indeed, the reconstructed ancestral motifs of all Indian M haplogroups turned out to be devoid of those variations that characterized M1, that is, 6446, 6680, 12403, and 14110 (Maca-Meyer et al. 2001;Herrnstadt et al. 2002). Therefore, those common mutations in the control region rather reflect random parallel mutations. [b]There is no evidence whatsoever that M1 originated in India.[/QUOTE][/b] [/QB][/QUOTE]There is nothing delusional in my proposition that M1 exist in India. Even Gonzalez (2007) admits that M1 was found in India and cites Kivisild et al (1999). Ana Gonzalez (2007) wrote The central HVSI haplotype (1612916189162231624916311) has been found only once in northwestern India [27]. Another possible Indian M1 candidate is the derived sequence: 160861612916223162491625916311 [28]. Gonzalez (2007) References: 27.Quintana-Murci L, Chaix R, Wells RS, Behar DM, Sayar H, Scozzari R, Rengo C, Al-Zahery N, Semino O, Santachiara-Benerecetti AS, Coppa A, Ayub Q, Mohyuddin A, Tyler-Smith C, Qasim Mehdi S, Torroni A, McElreavey K. Where West meets East: The complex mtDNA landscape of the Southwest and Central Asian corridor. Am J Hum Genet. 2004;74:827845. doi: 10.1086/383236. [PMC free article] [PubMed] [Cross Ref] 28.Kivisild T, Kaldma K, Metspalu M, Parik J, Papiha SS, Villems R. The place of the Indian mitochondrial DNA variants in the global network of maternal lineages and the peopling of the Old World. In: Deka R, Papiha SS, editor. Genomic diversity. New York: Kluwer/Academic/Plenum Publishers; 1999. pp. 135152. [/QB][/QUOTE]
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