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peer review demolishes Winters M-173
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[QUOTE]Originally posted by Troll Patrol # Ish Gebor: [QB] [QUOTE]Originally posted by Quetzalcoatl: [qb]The M1 reference is your own. It is not in the papers cited. See below for recurrent mutations. [/qb][/QUOTE]How can it be my own reference, when I cited Clyde Winters on this and asked you your opinion on it. While you responded with you other troll account.." I looked up the references myself: --Fucharoen, et al . “Mitochondrial DNA polymorphisms in Thailand,” J Hum Genet 46:115–125 http://download.bioon.com.cn/upload/20110610/2011061071.pdf -- Yao et a. Phylogeographic Differentiation of Mitochondrial DNA in Han Chinese Am J Hum Genet. 2002 Mar; 70(3): 635–651. Published online 2002 Feb 8. doi: 10.1086/338999 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384943/ [QUOTE]Originally posted by Quetzalcoatl: [qb] The difficulty here , and one that mystifies Clyde, are "recurrent mutations." Apparently some sites are more prone to mutations than others and thus can show up in different haplotypes. Thus it is important in determining a classification that all the identifying mutated SNPs be present. These are old papers by standards of the field-- I keep emphasizing that you need to check phylotree for changes that may have happened in the interval. M1 is defined by: T195C! G6446A T6680C C12403T A12950c G16129A! T16189C! T16249C T16311C! Yao, Y-G, et al 2002 “Phylogeographic Differentiation of Mitochondrial DNA in Han Chinese,” Am. J. Human Genetics 70:635-651 polymorphisms 16129 and 16249 were not found [/qb] [/QUOTE]I agree, these are old papers. So these "recurrent mutations" (16129, 16223 and 16311) have never been found in Africa? mtDNA Haplogroup Specific Control Region Mutation Motifs http://mtmanager.yonsei.ac.kr/help/MutationMotifs.pdf C16223T T16311C http://www.ncbi.nlm.nih.gov/pubmed/21042748 Apparently Clyde has more papers out, which have been recognized by NCBI. http://www.ncbi.nlm.nih.gov/pubmed/?term=Winters%20C%5Bauth%5D [/QB][/QUOTE]
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