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peer review demolishes Winters M-173
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[QUOTE]Originally posted by Troll Patrol # Ish Gebor: [QB] [QUOTE]Originally posted by Quetzalcoatl: [qb] [QUOTE]Originally posted by Troll Patrol # Ish Gebor: [qb] [QUOTE]Originally posted by Quetzalcoatl: [qb]The M1 reference is your own. It is not in the papers cited. See below for recurrent mutations. [/qb][/QUOTE]How can it be my own reference, when I cited Clyde Winters on this and asked you your opinion on it. While you responded with you other troll account.." I looked up the references myself: --Fucharoen, et al . “Mitochondrial DNA polymorphisms in Thailand,” J Hum Genet 46:115–125 http://download.bioon.com.cn/upload/20110610/2011061071.pdf -- Yao et a. Phylogeographic Differentiation of Mitochondrial DNA in Han Chinese Am J Hum Genet. 2002 Mar; 70(3): 635–651. Published online 2002 Feb 8. doi: 10.1086/338999 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384943/ [QUOTE]Originally posted by Quetzalcoatl: [qb] The difficulty here , and one that mystifies Clyde, are "recurrent mutations." Apparently some sites are more prone to mutations than others and thus can show up in different haplotypes. Thus it is important in determining a classification that all the identifying mutated SNPs be present. These are old papers by standards of the field-- I keep emphasizing that you need to check phylotree for changes that may have happened in the interval. M1 is defined by: T195C! G6446A T6680C C12403T A12950c G16129A! T16189C! T16249C T16311C! Yao, Y-G, et al 2002 “Phylogeographic Differentiation of Mitochondrial DNA in Han Chinese,” Am. J. Human Genetics 70:635-651 polymorphisms 16129 and 16249 were not found [/qb] [/QUOTE]I agree, these are old papers. So these "recurrent mutations" (16129, 16223 and 16311) have never been found in Africa? mtDNA Haplogroup Specific Control Region Mutation Motifs http://mtmanager.yonsei.ac.kr/help/MutationMotifs.pdf C16223T T16311C http://www.ncbi.nlm.nih.gov/pubmed/21042748 Apparently Clyde has more papers out, which have been recognized by NCBI. http://www.ncbi.nlm.nih.gov/pubmed/?term=Winters%20C%5Bauth%5D [/qb][/QUOTE]Sorry. Sometimes when the posts say "quote" too many times it is not clear to whom you are responding.my answer was meant for Clyde. Of course 16129, 16223, 163211 are found in Africa! They are the defining SNP's for M1 an African haplotype. Being listed in the NCI is not any kind of official recognition. If one is interested in what the quality of a particular journal, the place to look is the listing of impact factor of journals http://www.citefactor.org/journal-impact-factor-list-2014_I.html The only journal I found in which Winters published original articles (not comments or letters which as I have shown are not reviewed) was the [b]International Journal of Human genetics[/b]. This journal asked the author to send in the names of 3 proposed reviewers (in most peer reviewed journals editors choose the reviewers). Its impact factor is.0155 Journal impact factor Int. J Hum. genetics 0.155 PlOs ONE 4.411 BSC genetics 2.439 BSC genomics 3.716 Am. J Human genetics 10.987 Science 31.027 Nature 42.351 [/qb][/QUOTE]How can this be confusing. When I clearly addressed the question towards you. http://www.egyptsearch.com/forums/ultimatebb.cgi?ubb=get_topic;f=15;t=010625;p=4#000169 I am glade we have found common ground on M1 which is M. "[i]Of course 16129, 16223, 163211 are found in Africa! They are the defining SNP's for M1 an African haplotype. [/i]" [QUOTE][b]"The presence of M haplogroup in Ethiopia, named M1, led to the proposal that haplogroup M originated in eastern Africa, approximately 60,000 years ago, and was carried towards Asia [34].[/b] Macrohaplogroup M is ubiquitous in India and covers more than 70 per cent of the Indian mtDNA lineages [28], [36]–[38]. Recent studies on complete mtDNA sequences (~187) tried to resolve the phylogeny of Indian macrohaplogroup M. As a result, M2, M3, M4, M5, M6 [28], [36], [39]–[40], M18, M25 [38], M30, [41], M31 [42], [24] M33, M34, M35, M36, M37, M38, M39, M40 [22], M41, M42 [43], M43 [23], [44], M45 [45], M48, M49, and M50 [46] haplogroups of M that was identified in India helped to a certain extent in understanding M genealogy in diversified Indian populations. In the above background, extensive sequencing of complete mtDNA of South Asia, particularly India, is essential for better understanding of the peopling of the non-African continents, and pathogenesis of diseases in various ethnic groups with different matrilineal backgrounds."[/QUOTE]--Adimoolam Chandrasekar et al. 2009 Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor [/QB][/QUOTE]
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