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American Journal of Human Biology Volume 17, Issue 6 , Pages 690 - 695
An unexpected wide population variation of the G1733A polymorphism of the androgen receptor gene: Data on the Mediterranean region
E. Esteban
Abstract
The androgen receptor (AR) has been proposed as a candidate gene for several cancers (breast, prostate, uterine endometrium, colon, and esophagus). Ethnicity is considered an associated risk factor for some of these cancers. Several case-control genetic studies have been focused in samples of the main ethnic groups, but little is known about the distribution of risk polymorphisms in current populations with accurate ethnic and/or geographic origins. The A allele of the G1733A polymorphism of the AR gene has been associated with increased risk of prostate cancer. We provide data from this marker in 12 samples from 7 Mediterranean countries such as Spain, Italy (Sardinia), Greece, Turkey, Morocco, Algeria, and Egypt. A sample from Ivory Coast has also been analyzed. The A allele distribution shows a frequency in the Ivory Coast population (65.17%) that contrasts with the low values found in Northern Mediterraneans (mean average value of 13.98%). North African populations present two-times higher frequencies (average value of 27.19%) than Europeans. The wide population variation range found for the A allele strengthens the potential interest of further screening as a baseline to the design of future preventive and population health programs.
Supercar Member # 6477
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quote: Several case-control genetic studies have been focused in samples of the main ethnic groups, but little is known about the distribution of risk polymorphisms in current populations with accurate ethnic and/or geographic origins.
I am not sure what the significance of the new line of evidence is here?...Perhaps, the southward you go, the higher the frequency of the A allele distribution?
Thought2 Member # 4256
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"During the past few years a considerable number of epidemiological studies have demonstrated evidence of familial clustering of prostate cancer, suggesting that INHERITABLE factors may explain a substantial percentage of this disease risk. Ethnicity has been reported as an associated risk factor, and African American men have the highest incident rate of prostate cancer of any ethnic group in the United States..."
"...the G1733A polymorphism supports the hypothesis that genetic factor related to the androgen receptor may influence the behavior of human prostate cancer."
"...the distribution of G1733A plolymorphism has been studied in severeal epidemiological studies....frequencies in Europeans .... are low (around 10%)...."
"Previous data seems to indicate that this polymorphism VARIES LITTLE in populations other than those of Sub-Saharan African origin. The frequency of the A allele is very similar (around 13%) in Americans of European descent....However, in the Mediterranean groups here analyzed, the variation pattern of the A allele is clearly WIDER. The North African samples show frequencies two or three times higher than those reported in Europeans. The differences found suggest a certain degree of Sub-Saharan influence in the current North African population (more accentuated in southern Morrocco)...."
"The North African samples show frequencies two or three times higher than those reported in Europeans. The differences found suggest a certain degree of Sub-Saharan influence.."
European Average Frequency is .10% Greek Average Frequency is almost two times higher at .19%!!!!
Evil Euro Member # 6383
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And Basques' average frequency is highest of all the European samples listed (22%), while Turks' frequency (12%) is close to the European average despite their high levels of E3b. So there goes your entire "argument".
Djehuti Member # 6698
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quote:Originally posted by Evil Euro: And Basques' average frequency is highest of all the European samples listed (22%), while Turks' frequency (12%) is close to the European average despite their high levels of E3b. So there goes your entire "argument".
.13% is not a high frequency. All the high frequencies of E3b are found in East Africa which is why you are so desperate to make them caucasians! Give it up desperate dog!
osirion Member # 7644
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I dunno, this sounds comical to me.
Thought2 Member # 4256
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quote:Originally posted by Evil Euro: And Basques' average frequency is highest of all the European samples listed (22%), while Turks' frequency (12%) is close to the European average despite their high levels of E3b. So there goes your entire "argument".
Thought Writes:
What the hell are you babbling about now. E3b is a lineage derived primarily from Eastern Africa. G1733A, like the Benin Sickle Cell Variant seems to derive primarily from Western or Central Africa. Again, you have no point.
Evil Euro Member # 6383
posted West/Central African mtDNA in Europeans:
Greek - none = 0% Italian - 8/411 L = 1.9% Sicilian - 1/106 L2a = 0.9% Spanish - 9/419 L = 2.1%
Rosser et al. 2000 Wilson et al. 2001 Passarino et al. 2002 Rosenberg et al. 2002 DiGiacomo et al. 2003 Plaza et al. 2003 Brion et al. 2004 Flores et al. 2004 Semino et al. 2004 Pereira et al. 2005
KING Member # 9422
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Evil euro never gives up. Thats the only good thing I can say about him.
Djehuti Member # 6698
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quote:Originally posted by KING: Evil euro never gives up. Thats the only good thing I can say about him.
That is an understatement!!
The idiot has been going at it for what, almost 11 months now!! And about the same thing-- E3b is a "caucasoid" gene and East Africans are part caucasoid!
Seriously, despite his own (at least updated) evidence contradicting him, he continues to miscontrue and distort it all to fit his idiotic propaganda... for almost a YEAR on this forum!!!
Thought2 Member # 4256
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quote:Originally posted by Evil Euro: West/Central African mtDNA in Europeans:
Greek - none = 0% Italian - 8/411 L = 1.9% Sicilian - 1/106 L2a = 0.9% Spanish - 9/419 L = 2.1%
Rosser et al. 2000 Wilson et al. 2001 Passarino et al. 2002 Rosenberg et al. 2002 DiGiacomo et al. 2003 Plaza et al. 2003 Brion et al. 2004 Flores et al. 2004 Semino et al. 2004 Pereira et al. 2005
Thought Writes:
Please tell me SPECIFICALLY which one of these studies evaluates Greek dna in comparision to East, West, North, South and Central African dna. I will go and review your sources. If NONE of your sources compare and contrast these populations your point is moot.
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