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HLA genes in Southern Tunisians and their Relationship with other Med's
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[QUOTE]Originally posted by rasol: [QB] [QUOTE], the historical *facts* used in the study to support its conclusions are seriously flawed[/QUOTE]I agree that the non genetic remarks are flawed, but they have little bearing on the fact that Greeks show affinity with Africans via African Y chromosome lineages, and specific autosomes - such as Benin Hbs, as well as now two different HLA studies. All of this data is accurate and revealing if read properly- always the key with genetic study. [QUOTE]and from looking at the dendograms HLA genes are not reliable indicators to be used in population genetics. How do Japanese cluster with Africans?[/QUOTE]They don't, from the study -> [i]The Greeks have been shown a substantial Sub-Saharan admixture [30,31]. Bushmen and Japanese form an outgroup. [/i] :review dendrogram in figure 2. [b]Look at the horizontal length of the twigs[/b], as well as vertical relationships. What is suggested is ancient divergence of *both* Japanese and Bushmen from the other groups studied as far as HLA frequency is concerned - *not* recent ancestry between them. You have to look at all of the information, and understand what HLA genes are, and are not. They are not lineages, and should not be viewed as if they were. They simply suggest qualitative affinities between populations - without defining source/origin as lineages do. That Greeks have Black ancestry is [b]clear[/b]. Based on multiple studies of Y chromosome SNP markers, as well as Benin HBs autosome, and now two different HLA studies. Different methodologies: same conclusion. [/QB][/QUOTE]
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