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HLA genes in Southern Tunisians and their Relationship with other Med's
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[QUOTE]Originally posted by Supercar: [QB] [QUOTE]Originally posted by rasol: Correct, but Chang, et. al [2006] have->. [i][b]There is absolutely no evidence that M1 originated in India[/b].[/i][/QUOTE]True, and in getting to that point... What are we told about why the M1 could be closely related to Indian M haplogroup?… Well, for one, they all derive from L3, with origins in Africa. But then all non-African mtDNA ultimately derive from L3. And so, why is there the need to affiliate M1 with the Indian M haplogroup? We are told… [i]Due to the fact that M1 bears variant nucleotides, for example, at site 16311 in common with haplogroup M4, at 16129 with M5, and at 16249 with haplogroup M34, it has been proposed that M1 [b]might have[/b] some [b]affinity[/b] with Indian M haplogroups (Roychoudhury et al. 2001).[/i] - Chang Sun et al. One has to bear in mind though, concerning single nucleotide polymorphisms… [i]Interestingly, [b]a single M2 genome differs in its coding region from the root of M at ten sites as compared to M1[/b], which possess [b]only four substitutions[/b].[/i] - Revathi Rajkumar et al. …and what do we know about these aforementioned alleles of M1?… [i][b] Indeed, the reconstructed ancestral motifs of all Indian M haplogroups turned out to be devoid of those variations that characterized M1, i.e., 6446, 6680, 12403, and 14110[/b] (Maca-Meyer et al. 2001; Herrnstadt et al. 2002). Therefore, those common mutations in the control region rather reflect random parallel mutations.[/i] - Chang Sun et al. The conclusion… [i]There is no evidence whatsoever that M1 originated in India.[/i] - Chang Sun et al. [/QB][/QUOTE]
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