...
Post A Reply
my profile
|
directory
login
|
register
|
search
|
faq
|
forum home
»
EgyptSearch Forums
»
Egyptology
»
Mummy Genetics Study May Be Prelude To Widespread Genome Mapping Of Ancient Egyptians
» Post A Reply
Post A Reply
Login Name:
Password:
Message Icon:
Message:
HTML is not enabled.
UBB Code™ is enabled.
[QUOTE]Originally posted by Troll Patrol: [QB] [b]Ethiopian Mitochondrial DNA Heritage: Tracking Gene Flow Across and Around the Gate of Tears[/b] Am J Hum Genet. 2004 November; 75(5): 752–770. Published online 2004 September 27. PMCID: PMC1182106 Toomas Kivisild et al. [QUOTE] [b]Haplogroup M Lineages in Ethiopians and Yemenis[/b] Haplogroup M1 lineages constitute 17% of the Ethiopian mtDNA sequences, consistent with their high frequency in the region (Passarino et al. 1998; Quintana-Murci et al. 1999; Richards et al. 2003). Two subclades, which can be distinguished by coding-region RFLPs (Quintana-Murci et al. 1999)—M1a by 12345 RsaI (12346T) and M1b by 15883 AvaII (15884A)—together account for 56% of its variation. M1a is further characterized by a transition at np 16359 in HVS-I and is also present in the single Yemeni M1 sample (fig. 2B). M1a can be found together with M1* lineages in populations from the Near East, the Caucasus, and in Europe at marginally low frequencies (Corte-Real et al. 1996; Macaulay et al. 1999; Richards et al. 2000). The minor group M1b, defined by the motif 15884-16260-16320, is restricted to East Africans, having been observed, so far, only in Ethiopians (Quintana-Murci et al. 1999) and in Egypt (authors' unpublished results). It is interesting that the variable noncoding nucleotide 15884 also carries the derived A allele in one Moroccan M1* complete sequence, yet without the characteristic M1b HVS-I pattern (Maca-Meyer et al. 2001). M1a and M1b sequences are rare or absent in North Africans (Corte-Real et al. 1996; Rando et al. 1998; Brakez et al. 2001; Plaza et al. 2003). Instead, a third clade, M1c, defined by a transition at np 16185, covers most of haplogroup M1 variation in northwestern Africa, the Canary Islands, and the Near East. M1c has not been sampled yet among Ethiopians. It is intriguing that a Moroccan M1c complete sequence (Maca-Meyer et al. 2001) lacks the 813-6671-12950C mutations that define a common branch holding the M1a and M1b clades (fig. 4). It is notable that the other Moroccan M1 sequence with the 15884 mutation also lacks the 6671-12950C signature. In light of these data and because of the lack of other distinctive East African–specific mtDNA haplogroups in northwestern Africa, it is difficult to interpret the northwestern African haplogroup M1 variation as a derivative from the East African mtDNA pool. [/QUOTE] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182106/pdf/AJHGv75p752.pdf [/QB][/QUOTE]
Instant Graemlins
Instant UBB Code™
What is UBB Code™?
Options
Disable Graemlins in this post.
*** Click here to review this topic. ***
Contact Us
|
EgyptSearch!
(c) 2015 EgyptSearch.com
Powered by UBB.classic™ 6.7.3