...
Post A Reply
my profile
|
directory
login
|
register
|
search
|
faq
|
forum home
»
EgyptSearch Forums
»
Egyptology
»
Ancient west Eurasian ancestry in southern and eastern Africa 2013
» Post A Reply
Post A Reply
Login Name:
Password:
Message Icon:
Message:
HTML is not enabled.
UBB Code™ is enabled.
[QUOTE]Originally posted by The Explorer: [QB] [QUOTE]Originally posted by Swenet: Your lying ass was caught red handed making the retarded statement that derived SLC24A5 was selected for in a tropical environment, right here: [i]To the contrary, the paper only identifies skin pigmentation as the likely phenotypic candidate of this selection.[/i] --The Explorer[/QUOTE]As if you were not punished enough by a stunted brain, you are now a certified blind dingbat. Where does it say "tropical" in what you just quoted, or even this: [i]"derived SLC24A5 was selected for in a tropical environment"[/i]; where? And you accuse me of doing something retarded, retarded monkey. Stop the futile attempts at reading or thinking, foolish monkey. Neither suits you. [QUOTE]Troll, if skin pigmentation was the ’’likely phenotypic candidate of this selection’’[/QUOTE]numbskull, what you are quoting [incompletely] there, is just me telling you what the paper [b]actually[/b] notes about the SLC24A5 allele, as a contrast to your dumb monkey ass' [b]fairy tale[/b] "biological function". Correcting you--as this case shows superbly--is like adding fuel to gasoline. Instead of getting you educated, you get even more fat-ass crazy and out of control, LOL, because your stunted skull just cannot take accumulative inflow of real world information. [QUOTE] If not negative selection, explain why no other skin pigmentation genes were found in the Ethiopian population[/QUOTE]I thought I already clued in your stupid monkey ass that if there were no other skin pigmentation genes in Ethiopians, then they would not have any pigmentation. That's a no-brainer. There is just no way you have the smarts to even go to the toilet on your own or wear cloths on your own. FYI: This is the last time I'm telling you this; so get a care-taker who can read for you, moron. [QUOTE] [QUOTE]Originally posted by The Explorer: The piece you are citing says absolutely nothing about "weeding out"; those are your dumb words, not the authors.[/QUOTE]Of course it does. [/QUOTE]Because your block skull imagined it. That makes sense! LOL [QUOTE] Apparently your microcephalic head just cannot grasp the simple idea that SLC45A2 and other genes are a part of the package they tested for, but came up short. [/QUOTE]Indeed, I cannot grasp a simple stupid idea borne out of the crazy imagination of a complete lunatic. numbnut, they would neither be "looking for" nor applying Z-scores for a [fictitious] "[i]package of genes[/i]" that "[i][b]SlC24A5[/b][/i] (i.e. the correct gene; you can't even get the gene right) [i]is part of[/i]" (your stupid words of course), because they would have gotten right to the "[i]package of genes, that SLC24A5 is a part of[/i]" (your words, not the papers), as they would have known exactly where such a [silly fictitious] "package" would have been. Now let your care-taker spoon-feed you with reading, and learn, douchebag: [i]To [b]look for[/b] such outlier regions of admixture in Ethiopian populations (Semitic and Cushitic) where the estimated proportions of African and non-African ancestries were roughly equal, we [b]listed those regions showing an excess or a deficit (see Material and Methods) of non-African haplotypes [/b](Table S4). [b]Of the fourteen 40-SNP[/b] windows [b]observed with a Z-score > 2[/b], we [b]noted one that contained SLC24A5[/b] (MIM 113750). This gene is a major [b]contributor[/b] to the [b]pigmentation[/b] differences between Africans and Europeans and a strong candidate for positive selection in Europe.44,45 Given that SLC24A5 is one of the most highly differentiated genes between African and European populations,10,46 we then [b]looked for[/b] other highly differentiated genes10 among the outlier windows, but [b]found none[/b]. We also [b]checked whether[/b] the [b]24 large Z-score windows[/b] reported in Table S4 [b]showed enrichment for regions[/b] with [b]extreme distances between the African and non-African clouds[/b]. After [b]ranking all the 40-SNP windows[/b] by the distance between the African and European cloud centers divided by the SD of the European cloud around its center, [b]none of the large Z-score windows were present within the top 1%[/b]. We [b]therefore speculate[/b] that the [b]excess of[/b] non-African [b]SLC24A5 haplotypes must be linked[/b] to the [b]biological function[/b] of that gene.[/i] Instead, they would get right to doing this, as the authors did, only after having identified SLC24A5 locus as one suggestive of a "biological function" in the Ethiopian samples: [i]To [b]further[/b] investigate[/i] [meaning, this was not the primary focus of the tests] [i]the [b]effect of admixture[/b] on the [b]**genetic landscape of skin pigmentation** in Ethiopia[/b], we also [b]looked at[/b][/i] (notice it's not "looked for", douchebag) [i][b]other genes associated with pigmentation[/b] in Europe; however, [b]none were found in our outlier regions[/b].[/i] You should not be trying to learn genetics, which you don't even bother doing anyway; rather, you should be trying to catch up on reading 101, LOL. [QUOTE]I can always tell when it is dawning on you that you’re getting thrashed around the forum.[/QUOTE]Ooh, I'm shaking in my boots, because the fuckhead queen is "thrashing" me "around"...with utterly stupid zealotry crap. [QUOTE] Fix up that sick issue ridden narcissistic personality of yours, will ya? You have psychological issues.[/QUOTE]I know that you cannot possibly "fix up" your stunted thick skull--that ship has sailed; how about getting tampons to help "fix up" your PMS emotional attacks, fuckhead queen? [QUOTE]Speaking of which, explain why the non Ethio- Semitic/Cushitic speaking Ethiopians tested positive for the SLC24A5 gene in ways that are consistent with their respective size of the Syrian affinity having non-African haplotypes, if Ethiopian SLC24A5 is to be divorced from the said admixture event.[/QUOTE]dumbass chump, they have different bio-histories [while related]. How did you not get that? Well, you are dickheaded servant after all. [QUOTE]Stop lying, pig. They were investigating divergence patters which speak to admixture. The authors were looking for genes that experienced selection **after admixture** as indicated by the title of that segment of their paper.[/QUOTE]First you say they were "investigating patterns which speak to [b]admixture[/b]", then you say they were "looking for" genes that "[b]experienced selection[/b]" supposedly "after admixture". You are all over the place, and cannot make up your silly monkey mind up about what the primary goal was, just like a headless chicken hopping about everywhere. If this alone does not speak to that absent mind of your's, what else will? Fact of the matter is, as your dumb monkey ass was told, the authors had already decided upon which sequences to treat "African" and "non-African", henceforth why the study was fucked up. So they could not have been investigating "admixture", dumb servant. What about "selection"? Yes, they were trying to discern whether elements of their test sequences via distribution were suggestive of selection. The problem the authors faced, as your fat monkey ass was told, is: SLC24A5 variant in the Ethiopian groups was not accompanied by other "skin pigmentation" gene alleles whose distribution typically accompany that of SLC24A5 in "Europeans" and "west Asians". The phenotypic trait identified for the SLC24A5 variant argues against "selection" of the variant in an equatorial region, but the frequency of the variant suggests otherwise in Ethiopians. Thus the authors were compelled to reckon that "social factors" such as "sexual selection" may explain the distribution of SLC24A5 in Ethiopians. The problem with that reckoning has already been specified in my first post in this thread, but I won't hold my breath for you to read or understand it, and so, it is there for those with common sense and a reading skill of an educated adult. [QUOTE]You still have a cry baby emotion based struggle to come to grips with this basic fact, don’t you?[/QUOTE]The answer is of course a resounding "no", but you clearly do. This very post of yours is proof of it in itself. [QUOTE] [QUOTE]Originally posted by The Explorer: The only remotely relevant thing your Sri Lankan case can possibly have on our exchange, is one that is advantageous to me [/QUOTE]Two faced snake. Your inability to address what I’m shoving in your face for the second time speaks louder than your lying ass see-through professed unperturbedness. For the third time, lying ass troll, the Sri Lankan samples had an excess of SLC24A5, and a severe deficit of SLC45A2. Explain this under your crackpot theory that a severe minority of SLC24A5 correlated genes testify to an indigenous origin of this gene. [/QUOTE]Go ahead and ask many more times, the answer doesn't change, as was stated the last time you asked. Your reference to the Sri Lankan case is not only an irrelevant space waster, but also ironically, advantageous to me while damning to you, fuckhead queen. And guess what? This will be the last time I remind your numbskull of that too. :) [/QB][/QUOTE]
Instant Graemlins
Instant UBB Code™
What is UBB Code™?
Options
Disable Graemlins in this post.
*** Click here to review this topic. ***
Contact Us
|
EgyptSearch!
(c) 2015 EgyptSearch.com
Powered by UBB.classic™ 6.7.3