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Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by archaic introgression? - Yasukochi Y1, Ohashi J2.
Abstract A previous study reported that some of the human leukocyte antigen (HLA) alleles and haplotypes in present-day humans were acquired by admixture with archaic humans; specifically, an exceptionally diverged HLA-B*73 allele was proposed to be transmitted from Denisovans, although the DNA sequence of HLA-B*73 has not been detected in the Denisovan genome. Here, we argue against the hypothesis that HLA-B*73 introgressed from Denisovans into early modern humans. A phylogenetic analysis revealed that HLA-B*73:01 formed a monophyletic group with a chimpanzee MHC-B allele, strongly suggesting that the HLA-B*73 allelic lineage has been maintained in humans as well as in chimpanzees since the divergence of humans and chimpanzees. The global distribution of HLA-B*73 allele showed that the population frequency of HLA-B*73 in west Asia (0.24 %)-a possible site of admixture with Denisovans-is lower than that in Europe (0.72 %) and in south Asia (0.69 %). Furthermore, HLA-B*73 is not observed in Melanesia even though the Melanesian genome contains the highest proportion of Denisovan ancestry in present-day human populations. Single nucleotide polymorphisms in HLA-A*11-HLA-C*12:02 or HLA-A*11-C*15 haplotypes, one of which was assumed to be transmitted together with HLA-B*73 from Denisovans by the study of Abi-Rached and colleagues, were not differentiated from those in other HLA-A-C haplotypes in modern humans. These results do ****not**** support the introgression hypothesis. Thus, we conclude that it is highly likely that HLA-B*73 allelic lineage has been maintained in the direct ancestors of modern humans.
Elmaestro Member # 22566
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Jesus, was it the low freq in studied African pops in comparison to european populations that lead to the original hypothesis? what was the basis for that? ...anywho, being that it has a confirmed analog in the chimp, its safe to assume that some Afro pops will have HLA-B stand out more than others, for which we can maybe strengthen some hypothesis' in regards to relatedness by OOA-SSA populations and time of expansion, etc. etc.
xyyman Member # 13597
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The issue is “eyeballing”. Not all “Negros” are “Negros” and not all “Caucasians” are “Caucasians”. Africa is extremely diverse added to the fact there is Population “sub-structure” within Africa. Also many of use are missing a very fundamental point. Natufians/Basal Eurasian do NOT carry the supposed “Neanderthal” admixture in Eurasian. Lol! Proving yet again Neolithics are closely related to modern Africans or Europeans are a sub-set of modern Africans. They can spin every which way. They will never escape that fact. Time to close-up shop and move on. Lol!
Thereal Member # 22452
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I think any sensible person given an accurate history of the species would disagree with what's being tested,ducumented or reported,the issue is the white power structure doesn't want it,ethnic groups being ignorant of their or their neighbors history and some of these groups wielding power over others groups to keep them in a state of undevelopment.
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