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[QUOTE]Originally posted by Ish Gebor: [QB] [QUOTE]Originally posted by the lioness,: [qb] [QUOTE]Originally posted by Ish Gebor: [qb] Lioness can you explain why the title is [b]"Molecular Dissection Basal Clades in the Human Y Chromosome Phylogenetic Tree"?[/b] since I don't understand. :( The [i] "from the above article, the reference" [/i]is not from this paper. It's from a different paper. smh Can you explain why Cruciani places this R-M207 as the starting point, connect to seven mutations? Can you explain the existence with these seven mutations? [QUOTE] ‘‘Out of Africa’’ haplogroups. All Y-clades that are not exclusively African belong to the macro-haplogroup CT, which is defined by mutations M168, M294 and P9.1 [14,31] and is subdivided into two major clades, DE and CF [1,14]. In a recent study [16], sequencing of two chromosomes belonging to haplogroups C and R, led to the identification of 25 new mutations, eleven of which were in the C-chromosome and seven in the R-chromosome. Here, the seven mutations which were found to be shared by chromosomes of haplogroups C and R [16], were also found to be present in one DE sample (sample 33 in Table S1), and positioned at the root of macro-haplogroup CT (Figure 1 and Figure S1). [...] Three of the seven R-specific mutations (V45, V69 and V88) were previously mapped within haplogroup R [34], whereas the remaining four mutations have been here positioned at the root of haplogroups F (V186 and V205), K (V104) and P (V231) (Figure S1) through the analysis of 12 haplogroup F samples (samples 40–51, in Table S1). [...] Figure S1 Structure of the macro-haplogroup CT. For details on mutations see legend to Figure 1. Dashed lines indicate putative branchings (no positive control available). The position of V248 (haplogroup C2) and V87 (haplogroup C3) compared to mutations that define internal branches was not determined. Note that mutations V45, V69 and V88 have been previously mapped (Cruciani et al. 2010; Eur J Hum Genet 18:800–807). (TIF) Haplogroup affiliation for 51 Y chromosomes Table S1 analyzed in this study. (XLS) [/QUOTE]--Fulvio Cruciani et al. Molecular Dissection of the [b]Basal Clades [/b]in the Human Y Chromosome Phylogenetic Tree [/qb][/QUOTE]Your assumption is that in an article entitled Molecular Dissection of the Basal Clades in the Human Y Chromosome Phylogenetic Tree that any clade discussed is the earliest form of a haplogroup. That is not the case. [QUOTE] Molecular Dissection of the Basal Clades in the Human Y Chromosome Phylogenetic Tree Rosaria Scozzari, Andrea Massaia, Eugenia D’Atanasio, Natalie M. Myres, Ugo A. Perego, Beniamino Trombetta, Fulvio Cruciani Published: November 7, 2012 Abstract One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogeny by the analysis of 51 representative Y chromosome haplogroups and the use of 59 mutations from literature. Twenty-two new mutations were also described and incorporated in the revised phylogeny. This analysis made it possible to identify new haplogroups and to resolve a deep trifurcation within haplogroup B2. Our data provide a highly resolved branching in the African-specific portion of the Y tree and support the hypothesis of an origin in the north-western quadrant of the African continent for the human MSY diversity. [/QUOTE]^ They are discussing mutations stemming out of CT, they are not all basal clades [/qb][/QUOTE]Amusing, So explain how these seven mutations work at the base-level CT and why these are positioned at the root? How come on chromosomes was found in DE? [i]Here, the seven mutations which were found to be shared by chromosomes of haplogroups C and R [16], were also found to be present in one DE sample (sample 33 in Table S1), and positioned at the root of macro-haplogroup CT (Figure 1 and Figure S1). [/i] Explain why are the remainder four mutations of R positioned at the root of haplogroups F (V186 and V205)? Why is that? [QUOTE] Abstract Our data provide a highly resolved branching in the African-specific portion of the Y tree and support the hypothesis of an origin in the north-western quadrant of the African continent for the human MSY diversity. […] A new deep branch within the “out of Africa” haplogroup C was also identified [/QUOTE]—Fulvio Cruciani et al. Further more do C, CT, CF, F and DE have an African origin? [/QB][/QUOTE]
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