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What's the difference between genome-wide data and mitochondrial genomes?
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[QUOTE]Originally posted by xyyman: [QB] Maybe someone else can better explain. Continuing, this is what Hamblin et al states. Quote ---- Abstract While Simple Sequence Repeats (SSRs) are extremely useful genetic markers, [b]recent advances in technology have produced a shift toward use of single nucleotide polymorphisms (SNPs). [/b]The [b]different mutational properties of these two classes of markers [/b]result in differences in heterozygosities and allele frequencies that may have [b]implications for their use in assessing relatedness[/b] and evaluation of genetic diversity. We compared analyses based on 89 SSRs (primarily dinucleotide repeats) to analyses based on 847 SNPs in individuals from the same 259 inbred maize lines, which had been chosen to represent the diversity available among current and historic lines used in breeding. The[b] SSRs performed better at clustering germplasm into populations [/b]than did a set of 847 SNPs or 554 SNP haplotypes, and [b]SSRs provided more resolution in measuring genetic distance based on allele-sharing.[/b] Except for closely related pairs of individuals, measures of distance based on SSRs were only weakly correlated with measures of distance based on SNPs. [b]Our results suggest that 1) large numbers of SNP loci will be required to replace highly polymorphic SSRs in studies of diversity and relatedness[/b] and 2) relatedness among highly-diverged maize lines is difficult to measure accurately regardless of the marker system. --- What does it all mean? The Abusir mummies are not "Eurasian' if "Eurasian" means coming FROM Eurasia. They canNOT use frequency of SNPs to determine relatedness. Henn, Reich, Paabo etc . they ALL know this!!! It is a game played and laymen are caught up in the middle. Caught up in this "back-migration from Eurasia nonsense. The author(Hamblin) is stating that an infinite amount of SNPs is need to determine relatedness which is impossible The only way to determine related is through STRs/SSRs or uniparental markers like what the JAMA report did and DNATribes exposed and what the FBI uses through CODIS. The FBI do NOT use SNPs frequency because it is meaningLESS and cannot be used to catch a criminal. The novice reader do NOT know this. That is why STR showed the Amarna's were SSA and if the autosomal STRs (CODIS) is revealed for the Abusir mummies they too will be African. It is a game and the novice readers are the one being fooled. [/QB][/QUOTE]
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