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SOY Keita Comments on the "Black Pharaohs" Documentary from PBS
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[QUOTE]Originally posted by xyyman: [QB] Yeah! Yeah! Yeah! My man, You know you are slipping? Explain to the readers why Natufians NOW have Sub-saharan ancestry when it was not observed in prior studies. As I said back then it is impossible for Natufians NOT to be of African origin. Euros got the power(and information which they keep hidden) but Africans has always had the smarts and innovation ie Neolithics. Only a matter of time. This may probably go over the head of many but here goes.... ---------------------- Quote: Ancestry Estimation and Correction for Population Stratification in Molecular Epidemiologic Association Studies -Jill S [b]If AIMs are used instead of random markers, more falsepositive associations will result[/b] simply because the AIMs show large population differences in allele frequencies and there will be a tendency towards overcorrection (62). Genomic control, in general, is a relatively computationally easy method to implement and interpret. [b]We also discuss how to choose the appropriate genomic markers for ancestry estimation.[/b] AIMs and Ancestry Estimation Estimation of genetic ancestry can be achieved by genotyping AIMs. As defined above,[b] AIMs are** unlinked** markers found throughout the genome that show large allele frequency differences [/b](denoted d) between the relevant ancestral populations (21, 38-40). The two most commonly used methods for ancestry estimation from AIMs are maximum likelihood estimation (73, 74) and structured association clustering techniques as implemented in STRUCTURE (45, 51-53) and ADMIXMAP (46-50). These methods have been shown to be comparable in terms of accuracy (50, 52, 75), [b]but their** validity is dependent** on the informativeness of the panel of AIMs being used[/b] as well as the availability of allele and genotype frequency data (76). There are [b]currently several existing AIMs panels that can be implemented in genetic association studies[/b] (Table 1). Most of these panels consist of SNPs, [b]although some include **microsatellites**.[/b] The choice of markers depends on the marker’s ancestry informativeness, which depends on the value of d (38, 39, 81, 82). The choice can also depend on other population variables 79), such as the relative ancestral proportional contributions from each of the parental populations (77) and how many ancestral populations have mixed.[b] A practical understanding of the history of the immigration and migration history of the study population is critical to accurately select an appropriate panel of AIMs[/b]. Knowledge of this history is also critical to establish the [b]analytical models[/b] that require knowledge of how many and which of the ancestral parental populations should be considered for robust ancestry estimation. [b]Not all AIM panels are equivalent.[/b] For example, an AIMs panel assembled for Mexican Americans might be inappropriate for use in a Puerto Rican sample, because the level of African ancestry differs between these populations. Thus, estimation of ancestral proportions is highly dependent on (a) ----------------------- [QUOTE]Originally posted by Elmaestro: [qb] [QUOTE]Originally posted by xyyman: [qb] Henn also used LD to confirm it was always a South to North migration. ie LD is similar to STR. That is how we knew the Amarnas' were SSA regardless of the uniparental markers....which to date was never released. I would asume they were mtDNA U5b also ...SSA STR but "Eurasian" Haplgroups. eg Senegalese carrying U5b but SSA STR. Oh! But wait! Luxmanda carried Eurasian ancestry but African mtDNA L2a...wait! How does that work again(sic)? [/qb][/QUOTE]Download [b]Wordpad[/b] and veiw these two files.... Being that you know all about genetics and LD and all that Jaz you can figure out what's going on... If you have trouble for some reason (or if you're talking out the side of your neck), just scroll all the way down and look at [b]results[/b]... If you still can't interpret it, feel free to pm me. You'll probably glitch, time out, 404 crash when you do figure out what's going on though. But I'll give you leeway for a redemption arc. Hopefully you learn, so you can do the honors of breaking down whats going on here publicly for ES. https://drive.google.com/file/d/1xKGiUeiozEWkGLfokDpcdxJkzNJ1Sn3V/view?usp=sharing https://drive.google.com/file/d/1nM6FngaBWR9WPdyw8I4zbpzWcBMCkIJ1/view?usp=sharing [/qb][/QUOTE] [/QB][/QUOTE]
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