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Toward a more uniform sampling of human genetic diversity: A survey of worldwide populations by high-density genotyping
Jinchuan Xing, W. Scott Watkins, Adam Shlien, Erin Walker, Chad D. Huff, David J. Witherspoon, Yuhua Zhang, Tatum S. Simonson, Robert B. Weiss, Joshua D. Schiffman, David Malkinb, Scott R. Woodward and Lynn B. Jorde
Received 21 May 2010; accepted 13 July 2010. Available online 16 July 2010.
Abstract High-throughput genotyping data are useful for making inferences about human evolutionary history. However, the populations sampled to date are unevenly distributed, and some areas (e.g., South and Central Asia) have rarely been sampled in large-scale studies. To assess human genetic variation more evenly, we sampled 296 individuals from 13 worldwide populations that are not covered by previous studies. By combining these samples with a data set from our laboratory and the HapMap II samples, we assembled a final dataset of ~ 250,000 SNPs in 850 individuals from 40 populations. With more uniform sampling, the estimate of global genetic differentiation (FST) substantially decreases from ~ 16% with the HapMap II samples to ~ 11%. A panel of copy number variations typed in the same populations shows patterns of diversity similar to the SNP data, with highest diversity in African populations. This unique sample collection also permits new inferences about human evolutionary history. The comparison of haplotype variation among populations supports a single out-of-Africa migration event and suggests that the founding population of Eurasia may have been relatively large but isolated from Africans for a period of time. We also found a substantial affinity between populations from central Asia (Kyrgyzstani and Mongolian Buryat) and America, suggesting a central Asian contribution to New World founder populations.
Keywords: Single nucleotide polymorphism array; SNP; Population structure; Population diversity; Human population history
I call on Zarahan, Doc Scientia, MindOverMatter718, or anyone else for that matter, to please give me a quick heads up, if you happen to have the complete study in your possession and don't mind sharing it [even if privately]. Thanks.
Posts: 7516 | From: Somewhere on Earth | Registered: Jan 2008
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Check Bass's site(ESR). I heard all 12 pages are there.
sincerely anyone
Posts: 12143 | From: When you have eliminated the impossible, whatever remains, however improbable | Registered: Jun 2007
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^ Wow. Interesting study. So basically they're confirming that the Out-of-African migration ancestral to all Eurasians was a single event however the founding population that made this migration was much larger than previously thought. If this is so, then definitely these experts need to look back rethink about labeling certain haplogroups or even clades in Africa as being 'Eurasian' just because Eurasians carry them also.
Posts: 26238 | From: Atlanta, Georgia, USA | Registered: Feb 2005
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