We have resolved light skin in Europeans ala derived SLC24A5 dated at 100,000 old in Kenyans.
Now are they doing the smoke and mirrors thing with light skin in East Asians. We know north Asians are also white but the genes associated with that is different to Europeans...Kittles, Shriver and Norton et al.
Now have they found the gene associated with light skin in East Asians/Native Americans? And did it also come from Africa. Help me out here.
Man am I good or what!?
==================== A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia- Kaustubh Adhikari (2019)
Abstract We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12). We demonstrate the presence of multiple independent signals of association in the 11q14 and 15q13 regions (comprising the **GRM5/TYR **and HERC2/OCA2 genes, respectively) and several epistatic interactions among independently associated alleles. Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense variant (common only in East Asians and Native Americans) in **MFSD12,** a gene recently associated with skin pigmentation in Africans. We show that the frequency of the derived allele at Y182H is significantly correlated with lower solar radiation intensity in East Asia and infer that MFSD12 was under selection in East Asians, **probably*** after their split from Europeans.
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"probably, probably , probably?". Why are Europeans so twisted? Here they are hedging again by using the words probably. WTF is wrong with these people? So did Asian also back-migrate to Africa? (sic)
These people are mentally sick
What do you think?
-------------------- Without data you are just another person with an opinion - Deming Posts: 12143 | From: When you have eliminated the impossible, whatever remains, however improbable | Registered: Jun 2007
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Makes sense as the only difference between the Chinese looking negritos when compared to actually Chinese is color when they both have straight hair also didn't you make a thread on reloaded suggesting whites folks delusional stems in part because they lack melanin?
Posts: 1123 | From: New York | Registered: Feb 2016
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yes. It is called the VMAT1 gene i believe. It is on ESR
I agree they can't help themselves but it is irritating don't you think? I think it is tied to the cold adaptation and IBS. Found in 70% of Europeans.
I think the author is stating assume everyone of European descent has a mental dis-order. Xenophobia and racist? I don't agree with it but this is what he is saying. Keep in mind some Africans also carry the genes. So they are not home free- lol!
Quote: " at least for people of European descent, variation in the VMAT1 gene may confer susceptibility."
From Wiki ----------------- [b]Digestive system VMAT1 also has effects on the modulation of gastrin processing in G cells. These intestinal endocrine cells process amine precursors, and VMAT1 pulls them into vesicles for storage. The activity of VMAT1 in these cells has a seemingly inhibitory effect on the processing of gastrin. Essentially, this means that certain compounds in the gut can be taken into these G cells and either amplify or inhibit the function of VMAT1, which will impact gastrin processing (conversion from G34 to G17).[14]
Additionally, VMAT1 is known to play a role in the uptake and secretion of serotonin in the gut. Enterochromaffin cells in the intestines will secrete serotonin in response to the activation of certain mechanosensors.[15] The regulation of serotonin in the gut is critically important, as it modulates appetite and controls intestinal contraction.
Protection against hypothermia Presence of VMAT1 in cells has been shown to protect them from the damaging effects of cooling and rewarming associated with hypothermia.[16] Experiments were carried out on aortic and kidney cells and tissues. Evidence was found that an accumulation of serotonin using VMAT1 and TPH1 allowed for the subsequent release of serotonin when exposed to cold temperatures. This allows cystathionine beta synthase (CBS) mediated generation of H2S. The protection against the damage caused by hypothermia is due to a reduction in the generation of reactive oxygen species (ROS), which can induce apoptosis, due to the presence of H2S.[17]
Mental disorders VMAT1 (SLC18A1) maps to a shared bipolar disorder(BPD)/schizophrenia locus, which is located on chromosome 8p21.[18][19] It is thought that disruption in transport of monoamine neurotransmitters due to variation in the VMAT1 gene may be relevant to the etiology of these mental disorders. One study looked at a population of European descent, examining the genotypes of a bipolar group and a control group. The study confirmed expression of VMAT1 in the brain at a protein and mRNA level, and found a significant difference between the two groups, suggesting that, at least for people of European descent, variation in the VMAT1 gene may confer susceptibility.[18] A second study examined a population of Japanese individuals, one group healthy and the other schizophrenic. This study resulted in mostly inconclusive findings, but some indications that variation in the VMAT1 gene would confer susceptibility to schizophrenia in Japanese women.[20] While these studies provide some promising insight into the cause of some of the most prevalent mental disorders, it is clear that additional research will be necessary in order to gain a full understanding. ====================
-------------------- Without data you are just another person with an opinion - Deming Posts: 12143 | From: When you have eliminated the impossible, whatever remains, however improbable | Registered: Jun 2007
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