quote:Originally posted by InsertNameHere: It obviously has functional consequences. It also obviously lightens the skin, what it isn't obviously is albinism.
Edit: Though paleness is technically a symptom of albinism. So you could be correct to say the gene creates some of the same symptoms as albinism.
I like that your edit, you are now seeing better... maybe there is hope yet for you... I will tell you even more....
SLC24A5 is a gene common in all humanity including Africans and Asians and Europeans.
It is one of the makers of ancestry.
In a natural or ancestral form it contributes to the coding of the proteins necessary for the production of melanin.
In a "mutated" or "derived" form, it malfunctions and causes symptoms of Albinism.
Africans and Asians carry the anscestral form of SLC24A5.
Europeans carry the malfunctioning, mutated, or derived allelle which is responsible for albinism and other physiological dysfunctions...
I will provide sources....
SLC24A5 has a striking pattern of variation in human populations. A coding variant in the gene has previously been described as one of a set of ancestry-informative markers. The ancestral form encodes alanine at residue 111, whereas a derived allele encodes threonine. Alanine is present at this position in all known members of the SLC24 subfamily of proteins, suggesting the change to threonine has functional consequences .
The derived variant is universally present on all European chromosomes analysed, while chromosomes of African and Asian origin almost invariably carry the ancestral form...
posted
I beleive that to think that light skinned niggers did not come from my white grandfathers nutsacks is crazy. My great grandfather had him a many black wenches.
All Niggers should be floated back to Africa.
Posts: 220 | From: N.Y.C....Capital of the World | Registered: Mar 2010
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quote:Originally posted by InsertNameHere: It obviously has functional consequences. It also obviously lightens the skin, what it isn't obviously is albinism.
Edit: Though paleness is technically a symptom of albinism. So you could be correct to say the gene creates some of the same symptoms as albinism.
I like that your edit, you are now seeing better... maybe there is hope yet for you... I will tell you even more....
SLC24A5 is a gene common in all humanity including Africans and Asians and Europeans.
It is one of the makers of ancestry.
In a natural or ancestral form it contributes to the coding of the proteins necessary for the production of melanin.
In a "mutated" or "derived" form, it malfunctions and causes symptoms of Albinism.
Africans and Asians carry the anscestral form of SLC24A5.
Europeans carry the malfunctioning, mutated, or derived allelle which is responsible for albinism and other physiological dysfunctions...
I will provide sources....
SLC24A5 has a striking pattern of variation in human populations. A coding variant in the gene has previously been described as one of a set of ancestry-informative markers. The ancestral form encodes alanine at residue 111, whereas a derived allele encodes threonine. Alanine is present at this position in all known members of the SLC24 subfamily of proteins, suggesting the change to threonine has functional consequences .
The derived variant is universally present on all European chromosomes analysed, while chromosomes of African and Asian origin almost invariably carry the ancestral form...
SLC24A5 often occurs in Europeans in its homozygote form.
The homozygote forms of mutated or derived genes often cause all kinds of health problems. Albinism as we all know is associated with homozygote skin colour affecting allelles.
The high frequency of homozygote forms of SLC24A5 in Europeans indicate inbreeding over a long period of time.
We know that inbreeding leads to higher frequencies of albinism.
I will post my sources now:
Furthermore, analysis of the HapMap Consortium data6 found that SLC24A5 was within a chromosomal region that has a striking reduction of heterozygosity of SNPs in the European population. In fact, at 150 kb it is the longest such segment identified in the genome.1 Such a long conserved homozygous haplotype indicates that there has been strong selection on a gene or genes, which has swept this segment across the population, and selection for homozygosity eliminated recombination between SNPs, which maintained a long haplotype.
posted
Genetically they don't match up with known forms of albinism. This is fact. If it wasn't you would have found something that proved that the genes behind European paleness and albinism were identical. Even when the mutations are on the same gene albinos tend to have a section deleted while Europeans have one small part replaced or something similar, never in any case are they the same gene.
Please allow me to paraphrase:
We are NOT Albinos until we SAY we are Albinos!
Pardon me if I don't wait - you ARE Albinos!Posts: 22721 | Registered: Oct 2005
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posted
Yes, inbreeding also can lead to the wrong number of toes, it may even affect the shape of your nose.
I really don't care if they're inbred.
also just need to repeat this so you'll see it.
SLC24A5 does not affect eye color. That is produced by a variant of the P gene.
Edit: And you are rather correct, something really isn't an albino if the definition does not include it. Albino is a word with a certain definition that is tied to ocular function. If your definition of albino is anything with decreased melanin than of course whites are albinos. But that is not the proper definition.
But you are indeed correct that something is only named something if it is named something. There is a difference between normal albinism and white or Asian paleness no matter how slight it seems to you.
And it would be good for you to remember that Africa has the worlds highest diversity in skin color.
Posts: 195 | Registered: Jul 2010
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posted
In Africans and people of colour the gene responsible for coding the protein that underlies melanin is called MC1R.
European have only a mutated form of this gene. Just as is the case with albinos, the variants carried by Europeans don't function and thus cannot code properly for the proteins that make melanin.
This is the reason why like albinos they have pale skin, reddish or blond hair, and a propensity for skin burns and cancers...
I will also quote my sources:
...selection acting to maintain dark skin in African populations came from the MC1R gene. Variants of this gene are very common in Europeans, where in some populations, the majority of alleles are functionally impaired variants. Two variant alleles normally results in red hair and skin that has a greater susceptibility to UV burning.
posted
Europeans are not typically blonde and definitely not normally red-haired. Red hair may be relatively common in Europe but it is definitely not common.
You will probably also say that the blue eye variant of the P gene is also a form of albinism making Europeans require Three or Four forms of albinism to bring them to being as pale as an average albino.
Posts: 195 | Registered: Jul 2010
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quote:Originally posted by InsertNameHere: Just need to repeat this so you'll see it.
SLC24A5 does not affect eye color. That is produced by a variant of the P gene.
Europeans carry derived forms of SLC24A5 and SLC45A2.
Both are albino causing genes when they are in their derived forms...
Don't bring a red herring with SLC24A5 alone.
Additionally, many Europeans carry a mutated form of OCA 2 gene which we all know its dysfunctional effects... including eye colour and hair colour impacts..
And then there is also the KITG gene shared in its mutated form by many Europeans and this affects their eye colour.
The point is that, most of those genes are shared by the rest of the world but they are only malfucntional, dysfunctional in Europeans and Albinos.
The consequences of the dysfucntionalites are identical in albinos and Albions.....
Do you want me to cite more sources Mr. Insert??
Posts: 7419 | From: North America | Registered: Mar 2009
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quote:Originally posted by InsertNameHere: ...You will probably also say that the blue eye variant of the P gene is also a form of albinism making Europeans require Three or Four forms of albinism to bring them to being as pale as an average albino.
As you can see, the facts speak for themselves. If Europeans have a complex of damaged genes which produce albinsm symptoms in them ... as an ensemble or individually, that is what it is.
There are many genes responsible for skin and eye colour and their interaction is still being studied in science.
Yet, the complete or partial dysfunctionality of those genes combined or separately, meets all the conditions and symptoms for albinism...
Posts: 7419 | From: North America | Registered: Mar 2009
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posted
OCA2 is also a name for the P gene. And also your mention of KITG makes our average red-haired European require a whole SIX forms of albinism to make him his color. This seems a bit redundant when only one form would do just as well.
Edit: And how is the red hair of an Orangutan explained, or why Africans don't have dark eye whites like apes?
Posts: 195 | Registered: Jul 2010
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quote:Originally posted by InsertNameHere: Europeans are not typically blonde and definitely not normally red-haired. Red hair may be relatively common in Europe but it is definitely not common.
..
Blond and red hair colours are commonly seen variations in Europeans, but are rare in other populations....
quote:Originally posted by InsertNameHere: OCA2 is also a name for the P gene. And also your mention of KITG makes our average red-haired European require a whole SIX forms of albinism to make him his color. This seems a bit redundant when only one form would do just as well....
Not redundant... you are wrong again!
I cited authoritative sources including the European Journal of Medicine. The facts are what they are...sorry!
It implies that you have a very serious genetic problem. A complex of albinistic deficiencies of which etiology is multi-faceted.
Perhaps it explains why Europeans are fixed-Albinos.
But the facts are what they are...
Posts: 7419 | From: North America | Registered: Mar 2009
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posted
So any gene that makes you paler then the darkest of Africans makes you an albino? Than tell me how you lack brown eye whites? That too must be a form of albinism. Thus we are all albinos so this discussion is pointless.
Posts: 195 | Registered: Jul 2010
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quote:Originally posted by InsertNameHere: Commonly seen yes, but not typical. And many animals differ in melanin level from others, so are the ones paler one albinos too?
Edit:Calling white people brown haired would be more accurate.
Yes. Black rats are normal colour white rats are albino rats.
White rats are inbred, and have a host of genetic mutations responsible for their albinistic condition.
All white/pale variants of the colour are albinistic in nature.
My sources again:
Eye and hair colour is highly variable in the European population, and is largely genetically determined. Both linkage and association studies have previously been used to identify candidate genes underlying this variation. Many of the genes found were previously known as underlying mutant mouse phenotypes or human genetic disease, but others, previously unsuspected as pigmentation genes, have also been discovered.... See: http://www.biomedcentral.com/1471-2156/10/88
If white mice are are albinos every white cats are albios too. Yes sir...that it really true!
Posts: 7419 | From: North America | Registered: Mar 2009
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quote:Originally posted by InsertNameHere: So any gene that makes you paler then the darkest of Africans makes you an albino? Than tell me how you lack brown eye whites? That too must be a form of albinism. Thus we are all albinos so this discussion is pointless.
Don't be dumb and stubborn. The science has been cut and posted for you.
Refute the authorities..
Albinism (from Latin albus, "white"; see extended etymology, also called achromia, achromasia, or achromatosis) is a congenital disorder [a genetically inherited condition] characterized by:
the complete or partial absence of pigment in the skin, hair and eyes due to absence or defect of an enzyme involved in the production of melanin. [E.g. Mutated SLC45A2, and SLC24A5, OCA 2, KITLG];
Albinism results from inheritance of recessive gene alleles and is known to affect all vertebrates, including humans....
posted
Ah then why are there genes that only affect eye color that you claim are albinism. And there is such thing as ocular albinism which is named for affecting only the eyes. So explain to me how you are not an albino by your logic. How does not having pigmented eye whites not make you an albino?
Posts: 195 | Registered: Jul 2010
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quote:Originally posted by InsertNameHere: Nine types now
So why don't you have eye browns instead of whites?
You crack me up with your immature mind and denial... LoL!
The white of the eye-white, the white of the skeleton are all produced by the normal function of the proteins of the genetic codings underlaid by a complex of allelles ...
Do you for a moment think that the white of the eye is equivalent to the pale and pink skin of your butts?
Please answer with sources... Posts: 7419 | From: North America | Registered: Mar 2009
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posted
Quite olive skinned my self, thank you. If you won't explain eye whites, then explain the variation of skin color in Africa.
Posts: 195 | Registered: Jul 2010
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quote:Originally posted by InsertNameHere: Quite olive skinned my self, thank you. If you won't explain eye whites, then explain the variation of skin color in Africa.
I have done that for you many times tonight. But since your pink arse want some more beating, then here it is :
quote: -------------------------------------------------------------------------------- Originally posted by InsertNameHere: It obviously has functional consequences. It also obviously lightens the skin, what it isn't obviously is albinism.
Edit: Though paleness is technically a symptom of albinism. So you could be correct to say the gene creates some of the same symptoms as albinism. --------------------------------------------------------------------------------
I like that your edit, you are now seeing better... maybe there is hope yet for you... I will tell you even more....
SLC24A5 is a gene common in all humanity including Africans and Asians and Europeans.
It is one of the makers of ancestry.
In a natural or ancestral form it contributes to the coding of the proteins necessary for the production of melanin.
In a "mutated" or "derived" form, it malfunctions and causes symptoms of Albinism.
Africans and Asians carry the anscestral form of SLC24A5.
Europeans carry the malfunctioning, mutated, or derived allelle which is responsible for albinism and other physiological dysfunctions...
I will provide sources....
SLC24A5 has a striking pattern of variation in human populations. A coding variant in the gene has previously been described as one of a set of ancestry-informative markers. The ancestral form encodes alanine at residue 111, whereas a derived allele encodes threonine. Alanine is present at this position in all known members of the SLC24 subfamily of proteins, suggesting the change to threonine has functional consequences .
The derived variant is universally present on all European chromosomes analysed, while chromosomes of African and Asian origin almost invariably carry the ancestral form...
posted
Yes but why are some Africans darker than others.
And hair is white too when it lacks pigment. Most apes have pigmented whites. All humans differ from their fellow apes by having depigmented eye whites. It is not at all like bone.
Posts: 195 | Registered: Jul 2010
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The first is OCA1a, and means that the organism cannot develop pigment at all. ...
The second is OCA1b. Some individuals with OCA1b can tan and also develop pigment in the hair...
Another variant of OCA1b, called Albinism, yellow mutant type .... results in blonde hair and the eventual development of skin pigmentation during infancy
People with OCA2 generally have more pigment and better vision. This is the most common type of albinism, and it is caused by mutation of the P gene.
OCA3: It is caused by mutation of the tyrosinase-related protein-1 (Tyrp1) gene.
SLC45A2: OCA4 can only be distinguished from OCA2 through genetic testing, and is caused by mutation of the membrane-associated transporter protein (MATP) gene.
-------------------- Lionz Posts: 7419 | From: North America | Registered: Mar 2009
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quote:Originally posted by InsertNameHere: Yes but why are some Africans darker than others.
And hair is white too when it lacks pigment. Most apes have pigmented whites. All humans differ from their fellow apes by having depigmented eye whites. It is not at all like bone.
Red herring fallacy.
The thread is about Albinos and so-called whites and why they are so similar....
Well because they are suffering from the same genetic malfunction, and have almost exactly the same symptoms....
If you know why blacks are blacker tell me? Why is oliveskin black? Why are darker berries more tasty?
You answer...
I have cleared your Albino denial tonight. My job is done. You are now only wimpering about dark Africans. Fine.
But you no more deny you are pink and pale and share many similarities with the Albinos.
Case closed.
Posts: 7419 | From: North America | Registered: Mar 2009
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quote:Originally posted by InsertNameHere: I'm not pink. And I asked first about eye whites, so explain.
Dark Africans and eye-whites are off-topic. We are talking about the genetic basis of Albinism and its correlation with Europeans.
If you can correlate eye-white to albinism, then lay down your theory. I am willing to listen.
But do you have any more questions about the genes that cause Albinism? Ask me, I will oblige you again.
But I have no time for graspers, non-sequitor, playing to the gallery, or red herrings.
I have no time for semi-illiterate masochistic pink arses who come in all high and mighty only to be left grasping when hit with researched rebuttals.
Posts: 7419 | From: North America | Registered: Mar 2009
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posted
Also do you even know what olive skin is? Look it up dumbass, if you have it you aren't very dark at all.
Posts: 195 | Registered: Jul 2010
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quote:Originally posted by InsertNameHere: Yes, inbreeding also can lead to the wrong number of toes, it may even affect the shape of your nose.
I really don't care if they're inbred.
also just need to repeat this so you'll see it.
SLC24A5 does not affect eye color. That is produced by a variant of the P gene.
Edit: And you are rather correct, something really isn't an albino if the definition does not include it. Albino is a word with a certain definition that is tied to ocular function. If your definition of albino is anything with decreased melanin than of course whites are albinos. But that is not the proper definition.
But you are indeed correct that something is only named something if it is named something. There is a difference between normal albinism and white or Asian paleness no matter how slight it seems to you.
And it would be good for you to remember that Africa has the worlds highest diversity in skin color.
Your admissions are my proofs... Posts: 7419 | From: North America | Registered: Mar 2009
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quote:Originally posted by InsertNameHere: OCA2 is also a name for the P gene. And also your mention of KITG makes our average red-haired European require a whole SIX forms of albinism to make him his color. This seems a bit redundant when only one form would do just as well.
...blah blah blah
Your admission; My proof Posts: 7419 | From: North America | Registered: Mar 2009
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