posted
Humanity has entered a new genetic era, according to a newly published study, with well over half the mutations found having occurred "recently". Potentially troublesome genetic changes are particularly common among those of European heritage compared to those with African forebears, the research shows.
"The recent dramatic increase in human population size, resulting in a deluge of rare functionally important variation, has important implications for understanding and predicting current and future patterns of human disease and evolution," write the authors of the new report, published in Nature magazine.
The study involved gene sequencing carried out on 6,500 Americans of both African and European heritage. Some 73 per cent of the rare (occurring in less than 0.1 per cent of the sample) variations had occurred during the last 5,000 years.
Unfortunately a mutation is more likely to present a problem than an enhancement, and the human race in general is particularly full of them lately because of our massive population explosion over the last 5,000-odd years. Mutations are introduced in each new child (particularly if he or she has an older dad), so populations expanding fast from a small base naturally create more of them.
The relatively small group of mutant Africans who moved north into Europe have subsequently expanded in population particularly enormously, and as a result people of such stock are especially loaded with rare genetic variations.
"One of the most interesting points is that Europeans have more new deleterious (potentially disease-causing) mutations than Africans," says Dr. Suzanne Leal, professor of molecular and human genetics, one of the boffins who participated in the study.
Over the long previous history of humanity, bad mutations (or contra-reproduction ones, anyway) would be scrubbed away by people dying before they had a chance to have kids. But this is a slow process, and it has probably been slowed down even more by modern developments like buildings, farming, medicine etc, even as the rate of mutation has shot up massively.
So humanity is especially riddled with mutants and set to get more so. This could mean health problems - but it could also mean the future appearance of people who are truly unusual in what is generally considered very strange) ways.
Large-scale surveys of human genetic variation have reported signatures of recent explosive population growth4, 5, 6, notable for an excess of rare genetic variants, suggesting that many mutations arose recently. To more quantitatively assess the distribution of mutation ages, we resequenced 15,336 genes in 6,515 individuals of European American and African American ancestry and inferred the age of 1,146,401 autosomal single nucleotide variants (SNVs). We estimate that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years.
posted
They are finally admiting. Suprising this was actually published in a popular magazine.
The report is not suprising. Anyone living around white people will observed they are rife with genetic disease.
About 10 years ago every other report that came out hinted at Europeans being genetically superior. I knew it was more delusional BS feel good nonsense.
Letely I am getting the impression they are advocating "inter-racial" relation. Judging from the advertisement on TV, the movies etc.
I was suspicious of the trend. Maybe it is my imaginization but I am seing a lot more sista having white males as mates. This is new. Of course the black male/white female is also increasing.
Posts: 12143 | From: When you have eliminated the impossible, whatever remains, however improbable | Registered: Jun 2007
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quote:Originally posted by Narmerthoth: The study involved gene sequencing carried out on 6,500 Americans of both African and European heritage. Some 73 per cent of the rare (occurring in less than 0.1 per cent of the sample) variations had occurred during the last 5,000 years.
The relatively small group of mutant Africans who moved north into Europe have subsequently expanded in population particularly enormously, and as a result people of such stock are especially loaded with rare genetic variations.
Yes xyyman, I wondered why they chose to admit such damning info. in such a public forum myself; is the situation really that critical? Makes me think of one of those old science fiction movies: "Quick, round up some niggers, get busy making babies, we're dying out!"
But note the highlighted above:
Oxymoron Time.
They appear to be admitting that "Most" African Americans are actually "African/European/Americans.
The difference between the two groups is obviously a stay in Central Asia, and a lack of Melanin.
MK - I can't read the full text, what have they to say about those two things being the cause of defective genes?
Posts: 22721 | Registered: Oct 2005
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posted
Mike, as usual, Albinos are in the state of denial and attempt to turn a negative into a positive. They of course label OCA as a positive trait enabling Europeans to acquire Sunlight in loser UV environment, and this argument works well when the reader fails to understand that with little to no Eumelanin at specific ratios (to Phoemelanin), little to no captured sunlight is acquired in Albinos.
Also note, the article fails to mention that many specific physical traits such as blond hair, blue/green/grey eyes are the result of these same random mutations.
As expected, The article is a confession, but one laced with covering falsehoods.
It would have been appropriate for the authors to also tie in the results of a recent physical examination of 1000s of New York Ashkenazi Jews whose genetic mutation and disease rates leads the pack.
-------------------- Selenium gives real life and true reality Posts: 4693 | From: Saturn | Registered: Apr 2012
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"The relatively small group of mutant Africans who moved north into Europe have subsequently expanded in population particularly enormously, and as a result people of such stock are especially loaded with rare genetic variations."
They appear to be admitting that "Most" African Americans are actually "African/European/Americans.
Mike, bonehead, how does this make Americans of African ancestry European?
Narmertot, please correct Mike, he's trying to make it seem like the slave trade to America didn't happen again
______________________________________
Also the "mutant Africans" described who expanded enmormously in Europe are now known as "white people" of Europe.
when did the associated mutations occur? From the article:
"We estimate that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years. "
Posts: 42921 | From: , | Registered: Jan 2010
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(Nov. 28, 2012) — A study dating the age of more than 1 million single-letter variations in the human DNA code reveals that most of these mutations are of recent origin, evolutionarily speaking. These kinds of mutations change one nucleotide -- an A, C, T or G -- in the DNA sequence. Over 86 percent of the harmful protein-coding mutations of this type arose in humans just during the past 5,000 to 10,000 years. Some of the remaining mutations of this nature may have no effect on people, and a few might be beneficial, according to the project researchers. While each specific mutation is rare, the findings suggest that the human population acquired an abundance of these single-nucleotide genetic variants in a relatively short time. "The spectrum of human diversity that exists today is vastly different than what it was only 200 to 400 generations ago," said Dr. Joshua Akey, associate professor of genome sciences at the University of Washington in Seattle. He is one of several leaders of a multi-institutional effort among evolutionary geneticists to date the first appearance of a multitude of single nucleotide variants in the human population. Their findings appear in the Nov. 28 edition of Nature. The lead author is Dr. Wenqing Fu of the UW Department of Genome Sciences. The work stems from collaboration among many genome scientists, medical geneticists, molecular biologists and biostatisticians at the UW, the University of Michigan, Baylor College of Medicine in Houston, the Broad Institute at MIT and Harvard, and the Population Genetics Working Group. The study is part of the Exome Sequencing Project of the National Heart, Lung, and Blood Institute at the National Institutes of Health, To place this discovery in the context of the prehistory and ancient history of people, humans have been around for roughly 100,000 years. In the Middle East, cities formed nearly 8,500 years ago, and writing was used in Mesopotamia at least 5,500 years ago. The researchers assessed the distribution of mutation ages by re-sequencing 15,336 protein-coding genes in 6,515 people. Of them, 4,298 were of European ancestry, and 2,217 were African. The researchers based their explanation for the enormous excess of rare genetic variants in the present- day population on the Out-of-Africa model of the human diaspora to other parts of the world. "On average, each person has about 150 new mutations not found in either of their parents," Akey said. "The number of such genetic changes introduced into a population depends on its size." Larger populations, continuing to multiply by producing children, have more opportunities for new mutations to appear. The number of mutations thereby increases with accelerated population growth, such as the population explosion that began 5,115 years ago. During the Out of Africa migration of some early humans into Europe and beyond some 50,000 years past, a population bottleneck occurred: The number of humans plummeted, and the shrinking remnant became more genetically similar. Back then, mutations that were only slightly damaging had a greater probability of being carried from one generation to the next, Akey explained. "Those mutations don't influence the ability to survive and reproduce," he said. "The Out of Africa bottleneck led to inefficient purging of the less-harmful mutations." His group found that, compared to Africans, people of European descent had an excess of harmful mutations in essential genes -- those required to grow to adulthood and have offspring -- and in genes linked to Mendelian, or single-mutation diseases. The study team also observed that the older the genetic variant, the less likely it was to be deleterious. In addition, certain genes, they learned, harbored only younger, more damaging, mutations that surfaced less than 5,000 years ago. These include 12 genes linked to such diseases as premature ovarian failure, Alzheimer's, hardening of the heart arteries, and an inherited form of paralysis. Overall, the researchers predicted that about 81 percent of the single-nucleotide variants in their European samples, and 58 percent in their African samples, arose in the past 5,000 years. Older single- nucleotide variants -- first appearing longer than 50,000 years ago -- were more frequent in African samples. The scientists also noted that mutations affecting genes involved in metabolic pathways -- chemical reactions in the body to generate and tap energy -- tended not to be weeded out by selective forces. Aberrant metabolism contributes to diabetes, lipid disorders, obesity, and insulin resistance -- all common, modern scourges. The researchers pointed out that the results illustrate the profound effect recent human evolutionary history has had on the burden of damaging mutations in contemporary populations. "The historical details of human protein-coding variation provide practical information for prioritizing approaches to disease gene discovery," Akey said. Although the enlarged mutational capacity resulting from population growth has led to a greater incidence of genetic disorders among the world's 7 billion people, there is brighter side to the story. Mutations have fostered the great variety of traits seen among modern humans, according to the researchers, who added, "They also may have created a new repository of advantageous genetic variants that adaptive evolution may act upon in future generations."
Posts: 42921 | From: , | Registered: Jan 2010
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posted
^ Yet as usual as attempted with the "Europeans recently turned White In Europe" fake paper, this paper is consistent in attempting to pass off the same rather than the more obvious, Albinism migrated to Europe from OOA.
-------------------- Selenium gives real life and true reality Posts: 4693 | From: Saturn | Registered: Apr 2012
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quote:Originally posted by the lioness,: Also the "mutant Africans" described who expanded enmormously in Europe are now known as "white people" of Europe.
Lioness - I don't recall reading that, or anything "SUGGESTING" that. Would you please reference that paragraph that you are lying about.
Posts: 22721 | Registered: Oct 2005
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posted
Albinos are becoming desperate to change damaged DNA. Damaged minds mutate damaged hybrids.
Genetically modified mutants 'safe for release' into the wild 'Underdominance' experiment on remote island
Remorseless German scientists say that the time may now be ripe for scientists to begin release of "transgenic individuals into populations". Concerns that this might result in those populations being completely replaced by the superior lab-developed individuals can be addressed, they say, by the use of cunningly selected mutants.
Rather than some kind of sinister play to replace unsatisfactory human beings with superior lab-grown varieties, this is actually aimed at helping people – for instance by wiping out the terrible menace of mosquito-borne malaria, one of the most potent threats to human health around.
According to the geneticists of the Max Planck Institute for Evolutionary Biology in Plön:
Populations containing mutants with heterozygote disadvantage develop into one of two stable states. These mutant types therefore seem to be well-suited for the safe release of genetically modified organisms. After all, as soon as sufficient numbers of mutants exist in the environment, these replace the natural variant in a local population. If such genes are joined to resistance genes to combat pathogens, mosquito populations could be rendered resistant to malaria, for example. By releasing the wildtype at a later stage, the transgenic animals can therefore also be removed again more easily from the environment. In population genetics this is known as underdominance.
In traditional style when speaking of creating artificial monsters in a completely safe experiment, the plan is to do so at first on a remote island – just to be sure.
quote:Originally posted by Narmerthoth: Humanity has entered a new genetic era, according to a newly published study, with well over half the mutations found having occurred "recently". Potentially troublesome genetic changes are particularly common among those of European heritage compared to those with African forebears, the research shows.
"The recent dramatic increase in human population size, resulting in a deluge of rare functionally important variation, has important implications for understanding and predicting current and future patterns of human disease and evolution," write the authors of the new report, published in Nature magazine.
The study involved gene sequencing carried out on 6,500 Americans of both African and European heritage. Some 73 per cent of the rare (occurring in less than 0.1 per cent of the sample) variations had occurred during the last 5,000 years.
Unfortunately a mutation is more likely to present a problem than an enhancement, and the human race in general is particularly full of them lately because of our massive population explosion over the last 5,000-odd years. Mutations are introduced in each new child (particularly if he or she has an older dad), so populations expanding fast from a small base naturally create more of them.
The relatively small group of mutant Africans who moved north into Europe have subsequently expanded in population particularly enormously, and as a result people of such stock are especially loaded with rare genetic variations.
"One of the most interesting points is that Europeans have more new deleterious (potentially disease-causing) mutations than Africans," says Dr. Suzanne Leal, professor of molecular and human genetics, one of the boffins who participated in the study.
Over the long previous history of humanity, bad mutations (or contra-reproduction ones, anyway) would be scrubbed away by people dying before they had a chance to have kids. But this is a slow process, and it has probably been slowed down even more by modern developments like buildings, farming, medicine etc, even as the rate of mutation has shot up massively.
So humanity is especially riddled with mutants and set to get more so. This could mean health problems - but it could also mean the future appearance of people who are truly unusual in what is generally considered very strange) ways.
Large-scale surveys of human genetic variation have reported signatures of recent explosive population growth4, 5, 6, notable for an excess of rare genetic variants, suggesting that many mutations arose recently. To more quantitatively assess the distribution of mutation ages, we resequenced 15,336 genes in 6,515 individuals of European American and African American ancestry and inferred the age of 1,146,401 autosomal single nucleotide variants (SNVs). We estimate that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years.
Now look to Narmertot's edited version of the last sentence of the Register article and compare to the original:
Narmertot:
So humanity is especially riddled with mutants and set to get more so. This could mean health problems - but it could also mean the future appearance of people who are truly unusual in what is generally considered very strange) ways.
Original article:
_________________________________________
also from the Register article and proprely quoted by Narmertot:
"The relatively small group of mutant Africans who moved north into Europe have subsequently expanded in population particularly enormously, and as a result people of such stock are especially loaded with rare genetic variations.
'One of the most interesting points is that Europeans have more new deleterious (potentially disease-causing) mutations than Africans,' says Dr. Suzanne Leal, professor of molecular and human genetics, one of the boffins who participated in the study."
^^^^ Mike everyone but you understood what was being said here,
mutant Africans who moved north into Europe have subsequently expanded in population particularly enormously, and as a result people of such stock are especially loaded with rare genetic variations.
'One of the most interesting points is that Europeans
The "mutant Africans" they are mentioning who "subsequently expanded in population particularly enormously" are the ancestors of modern Europeans. That is also made clear in the first sentence of the next paragraph "One of the most interesting points is that Europeans"
^^^^ the "mutant Africans" are the Europeans, ancestors of the modern Europeans
And none of this has to do with Afircan Americans -we came direct from Africa
Early Africans who went into Europe disappeared before written history began due to the ice age, starving or migrating back into Africa. The Africans who entered back into Europe in the Neolithic, as the article states, were the mutant Africans aka white people. Of course all the variation inside Africa is also the result of mutation ongoing that is stretched out over hundreds of thousands of years. They are referring in this article to what happens in population bottlenecks with a relatively very rapid population increase. Much of it is due to technology, the adevent of farming and into modern farming, vaccines etc.
Posts: 42921 | From: , | Registered: Jan 2010
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quote:Originally posted by the lioness,: Narmertot didn't source this article in the Register (UK) that spoke about the Nature article because he mutated the last sentence of the article.
What else do you expect of a retarded 50 year old geezer who subscribes to fortune telling and astrology, aliens, melanin theory and widely recognized quacks (Jewel Pookrum) who have blood on their hands.
When you can't get science behind you, the next best thing is misconstruing the literature, and then having the audacity to put on a front that you're in the position to be criticizing ''albino'' scholars for their supposed habit of telling lies. B!tch, all you do is lie.
Posts: 8785 | From: Discovery Channel's Mythbusters | Registered: Dec 2009
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quote:Originally posted by the lioness,: Narmertot didn't source this article in the Register (UK) that spoke about the Nature article because he mutated the last sentence of the article.
What else do you expect of a retarded 50 year old geezer who subscribes to fortune telling and astrology, aliens, melanin theory and widely recognized quacks (Jewel Pookrum) who have blood on their hands.
When you can't get science behind you, the next best thing is misconstruing the literature, and then having the audacity to put on a front that you're in the position to be criticizing ''albino'' scholars for their supposed habit of telling lies. B!tch, all you do is lie.
Why do you insist on making yourself appear like an ignorant simple Albino ingrate. Especially when every reader sees that so far you have presented NO form of counter argument to the melanin reality. Not once!
Why? Simply if you can't dispute the information, present FUD (FEAR, Uncertainty, Doubt) with personal attacks on the messenger or divert the discussion to cackling gibberish.
The reality is, you really are an ignorant albino ingrate who has no scientific information to offer opposing counter results, different then what has been posted.
The various reports supporting the life defining characteristics of Melanin were researched and presented by medical Doctors, Public Health agencies, scientists, and geneticists of varying ages, from around the world. How can a fool like you entertain thoughts of refuting sources such as this whose research validates Dr. Pookrum; http://www.pigment.org/melaninchemistry.asp
Whose research are you referencing?
Posts: 4693 | From: Saturn | Registered: Apr 2012
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posted
Don't forget this is the same dude who believes in Astro-projection and the "Moorish Science" cult..
LMAO, the dude is worse than Afronut/Gigantic..
quote:Originally posted by Swenet:
quote:Originally posted by the lioness,: Narmertot didn't source this article in the Register (UK) that spoke about the Nature article because he mutated the last sentence of the article.
What else do you expect of a retarded 50 year old geezer who subscribes to fortune telling and astrology, aliens, melanin theory and widely recognized quacks (Jewel Pookrum) who have blood on their hands.
When you can't get science behind you, the next best thing is misconstruing the literature, and then having the audacity to put on a front that you're in the position to be criticizing ''albino'' scholars for their supposed habit of telling lies. B!tch, all you do is lie.
Posts: 8804 | From: The fear of his majesty had entered their hearts, they were powerless | Registered: Nov 2007
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quote:Originally posted by -Just Call Me Jari-: Don't forget this is the same dude who believes in Astro-projection and the "Moorish Science" cult..
LMAO, the dude is worse than Afronut/Gigantic..
quote:Originally posted by Swenet:
quote:Originally posted by the lioness,: Narmertot didn't source this article in the Register (UK) that spoke about the Nature article because he mutated the last sentence of the article.
What else do you expect of a retarded 50 year old geezer who subscribes to fortune telling and astrology, aliens, melanin theory and widely recognized quacks (Jewel Pookrum) who have blood on their hands.
When you can't get science behind you, the next best thing is misconstruing the literature, and then having the audacity to put on a front that you're in the position to be criticizing ''albino'' scholars for their supposed habit of telling lies. B!tch, all you do is lie.
Jari You know what's up. Don't be so eager to play the giggling transsexual cheerleader.
Posts: 4693 | From: Saturn | Registered: Apr 2012
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posted
'One of the most interesting points is that Europeans have more new deleterious (potentially disease-causing) mutations than Africans,' says Dr. Suzanne Leal, professor of molecular and human genetics, one of the boffins who participated in the study."
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